Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC108267519Insulin receptor substrate 1-B-like. (1244 aa)    
Predicted Functional Partners:
LOC108267827
Tyrosine-protein kinase receptor.
    
 0.982
LOC108256494
Growth factor receptor-bound protein 2.
    
 0.976
grb2
Growth factor receptor-bound protein 2 isoform X1.
    
 0.976
pik3r3
Phosphatidylinositol 3-kinase regulatory subunit alpha.
    
 0.974
pik3r1
Phosphatidylinositol 3-kinase regulatory subunit alpha.
    
 0.974
LOC108271091
Tyrosine-protein kinase receptor.
    
 0.971
igf1r
Tyrosine-protein kinase receptor.
    
 0.971
pik3ca
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.960
LOC108275608
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.960
pik3cd
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.959
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: low (20%) [HD]