Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
tlr3Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family. (905 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.976
LOC100304977
TIR-containing adaptor molecule.
    
 0.962
LOC108273898
Interferon regulatory factor 3-like.
    
 0.933
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.906
tbk1
Serine/threonine-protein kinase TBK1 isoform X1.
   
 0.796
irak4
Interleukin-1 receptor-associated kinase 4.
    
 0.792
irf7
Interferon regulatory factor 7.
     
 0.775
ifih1
Interferon-induced helicase C domain-containing protein 1.
   
 
 0.762
traf3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.756
unc93b1
Protein unc-93 homolog B1.
    
 0.755
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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