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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
LOC108259691RUN domain-containing protein 3A-like isoform X1. (435 aa)    
Predicted Functional Partners:
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
   0.866
bmp2k
BMP-2-inducible protein kinase isoform X2.
    
   0.857
LOC108265343
AP2-associated protein kinase 1-like isoform X1.
    
   0.749
LOC108276848
AP2-associated protein kinase 1-like isoform X2.
    
   0.749
ralbp1
ralA-binding protein 1 isoform X1.
    
   0.715
ap2a1
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
   0.708
ap2a2
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
   0.708
LOC108267679
AP-2 complex subunit mu-A-like isoform X1; Belongs to the adaptor complexes medium subunit family.
   
   0.665
LOC108264350
AP-2 complex subunit mu-B.
   
   0.665
tmem19
Transmembrane protein 19.
      
 0.629
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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