Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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LOC108262486Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)    
Predicted Functional Partners:
arid4a
AT-rich interactive domain-containing protein 4A.
    
 0.738
arid4b
AT-rich interactive domain-containing protein 4B isoform X2.
    
 0.738
LOC108261415
Histone H2A; Belongs to the histone H2A family.
   
 0.719
LOC108261415-2
Histone H2A.
   
 0.719
LOC108261415-3
Histone H2A.
   
 0.719
LOC108261415-4
Histone H2A.
   
 0.719
LOC108261415-5
Histone H2A.
   
 0.719
hat1
Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.
    
 0.705
LOC108260489
Histone H2B; Belongs to the histone H2B family.
   
 0.679
ENSIPUP00000009144
Histone H2B 3.
   
 0.679
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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