Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC108261472Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family. (521 aa)    
Predicted Functional Partners:
LOC100304475
3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase; Belongs to the 3-beta-HSD family.
   
 0.970
cyp11a
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.948
hsd11b2
Corticosteroid 11-beta-dehydrogenase isozyme 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.947
akr1d1
3-oxo-5-beta-steroid 4-dehydrogenase isoform X1.
   
 
 0.927
hsd11b1l
Hydroxysteroid 11-beta-dehydrogenase 1-like protein.
   
 
 0.922
LOC108270649
25-hydroxycholesterol 7-alpha-hydroxylase-like isoform X1; Belongs to the cytochrome P450 family.
  
  
0.921
LOC108275468
Steroid 17-alpha-hydroxylase/17,20 lyase-like isoform X1; Belongs to the cytochrome P450 family.
  
  
0.918
cyp17
Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
  
  
0.915
srd5a2
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
     
 0.913
srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
     
 0.913
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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