Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
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Score
trip12E3 ubiquitin-protein ligase TRIP12. (2073 aa)    
Predicted Functional Partners:
ubr1
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 0.993
ubr2
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
 0.993
rps27a
Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]
    
 0.989
usp7
Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family.
   
 
 0.984
LOC108267183
Ubiquitin-like isoform X2.
   
  0.970
uba52
ubiquitin-60S ribosomal protein L40 isoform X1.
   
  0.970
ENSIPUP00000020146
annotation not available
   
  0.970
psmc5
26S protease regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family.
    
 
 0.961
USP34
Ubiquitin carboxyl-terminal hydrolase 34 isoform X2; Belongs to the peptidase C19 family.
   
 
 0.957
ube4a
Ubiquitin conjugation factor E4 A.
   
 0.951
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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