Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC108258691Actin, cytoplasmic 1. (375 aa)    
Predicted Functional Partners:
LOC108275705
Profilin; Belongs to the profilin family.
   
 0.957
pfn2
Profilin; Belongs to the profilin family.
   
 0.957
cfl2
Cofilin-2; Belongs to the actin-binding proteins ADF family.
   
 0.952
cfl1
Cofilin-1; Belongs to the actin-binding proteins ADF family.
   
 0.952
arpc2
Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
   
 0.951
iqgap1
Ras GTPase-activating-like protein IQGAP1.
    
 0.948
wasf1
wiskott-Aldrich syndrome protein family member 1 isoform X1.
    
 0.947
wasf2
wiskott-Aldrich syndrome protein family member 2.
    
 0.947
LOC108261049
Cofilin-2-like; Belongs to the actin-binding proteins ADF family.
   
 0.946
LOC108273866
LOW QUALITY PROTEIN: vinculin-like.
   
 0.944
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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