Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
hps4Hermansky-Pudlak syndrome 4 protein isoform X1. (632 aa)    
Predicted Functional Partners:
hps1
Hermansky-Pudlak syndrome 1 protein isoform X1.
     
 0.922
hgd
Homogentisate 1,2-dioxygenase.
  
 0.921
tat
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
 
 0.817
bloc1s3
Biogenesis of lysosome-related organelles complex 1 subunit 3.
    
 0.694
LOC108265604
Putative methylcrotonoyl-CoA carboxylase beta chain, mitochondrial.
  
 
 0.680
pccb
propionyl-CoA carboxylase beta chain, mitochondrial.
  
 
 0.680
mccc2
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial.
  
 
 0.680
hps6
Hermansky-Pudlak syndrome 6 protein.
     
 0.679
coq2
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
     
 0.651
hps3
Hermansky-Pudlak syndrome 3 protein isoform X1.
      
 0.618
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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