Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pms2Mismatch repair endonuclease PMS2. (857 aa)    
Predicted Functional Partners:
mlh1
DNA mismatch repair protein Mlh1.
   
0.999
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.998
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.998
fan1
Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.
   
 0.996
msh3
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.989
brip1
Fanconi anemia group J protein isoform X1.
   
 0.986
exo1
Exonuclease 1 isoform X1.
   
 0.977
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.967
pold1
DNA polymerase.
   
 
 0.937
pole
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 
 0.917
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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