Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC1003044753 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase; Belongs to the 3-beta-HSD family. (374 aa)    
Predicted Functional Partners:
cyp17
Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
   
 0.981
LOC108264511
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
   
 0.975
LOC108270649
25-hydroxycholesterol 7-alpha-hydroxylase-like isoform X1; Belongs to the cytochrome P450 family.
   
 0.973
LOC108275468
Steroid 17-alpha-hydroxylase/17,20 lyase-like isoform X1; Belongs to the cytochrome P450 family.
   
 0.970
LOC108261472
Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family.
   
 0.970
cyp11a
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 0.967
srd5a3
Polyprenol reductase.
     
 0.961
LOC108278029
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.959
LOC108267573
Cholesterol 7-alpha-monooxygenase-like isoform X2.
   
 0.959
hsd17b3
Testosterone 17-beta-dehydrogenase 3 isoform X1.
  
 0.953
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.