LOC108266573 protein (Ictalurus punctatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LOC108266573

Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5. (1175 aa)

Predicted Functional Partners:

etnppl

0.684

LOC108279607

0.616

LOC108271628

0.616

nck1

0.518

nck2

0.518

LOC108273233

0.518

lats2

0.512

lats1

0.508

txn

0.444

LOC108263754

0.444

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108263754	LOC108266573	ENSIPUP00000013902	ENSIPUP00000006901	Thioredoxin; Belongs to the thioredoxin family.	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	0.444
LOC108263754	txn	ENSIPUP00000013902	ENSIPUP00000010620	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.901
LOC108266573	LOC108263754	ENSIPUP00000006901	ENSIPUP00000013902	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Thioredoxin; Belongs to the thioredoxin family.	0.444
LOC108266573	LOC108271628	ENSIPUP00000006901	ENSIPUP00000029368	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Craniofacial development protein 2-like.	0.616
LOC108266573	LOC108273233	ENSIPUP00000006901	ENSIPUP00000017982	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Cytoplasmic protein NCK2-like.	0.518
LOC108266573	LOC108279607	ENSIPUP00000006901	ENSIPUP00000029198	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Uncharacterized protein LOC108279607.	0.616
LOC108266573	etnppl	ENSIPUP00000006901	ENSIPUP00000029182	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Ethanolamine-phosphate phospho-lyase isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.684
LOC108266573	lats1	ENSIPUP00000006901	ENSIPUP00000014369	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Serine/threonine-protein kinase LATS1.	0.508
LOC108266573	lats2	ENSIPUP00000006901	ENSIPUP00000005380	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Serine/threonine-protein kinase LATS2.	0.512
LOC108266573	nck1	ENSIPUP00000006901	ENSIPUP00000001267	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Cytoplasmic protein.	0.518
LOC108266573	nck2	ENSIPUP00000006901	ENSIPUP00000007215	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Cytoplasmic protein.	0.518
LOC108266573	txn	ENSIPUP00000006901	ENSIPUP00000010620	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.444
LOC108271628	LOC108266573	ENSIPUP00000029368	ENSIPUP00000006901	Craniofacial development protein 2-like.	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	0.616
LOC108271628	etnppl	ENSIPUP00000029368	ENSIPUP00000029182	Craniofacial development protein 2-like.	Ethanolamine-phosphate phospho-lyase isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.600
LOC108273233	LOC108266573	ENSIPUP00000017982	ENSIPUP00000006901	Cytoplasmic protein NCK2-like.	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	0.518
LOC108273233	nck1	ENSIPUP00000017982	ENSIPUP00000001267	Cytoplasmic protein NCK2-like.	Cytoplasmic protein.	0.909
LOC108273233	nck2	ENSIPUP00000017982	ENSIPUP00000007215	Cytoplasmic protein NCK2-like.	Cytoplasmic protein.	0.902
LOC108279607	LOC108266573	ENSIPUP00000029198	ENSIPUP00000006901	Uncharacterized protein LOC108279607.	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	0.616
LOC108279607	etnppl	ENSIPUP00000029198	ENSIPUP00000029182	Uncharacterized protein LOC108279607.	Ethanolamine-phosphate phospho-lyase isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.600
etnppl	LOC108266573	ENSIPUP00000029182	ENSIPUP00000006901	Ethanolamine-phosphate phospho-lyase isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Mitogen-activated protein kinase kinase kinase kinase 4-like isoform X5.	0.684