STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyldUbiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (768 aa)    
Predicted Functional Partners:
tnfrsf1a
Tumor necrosis factor receptor superfamily member 1A.
    
 0.949
ikbkg
NF-kappa-B essential modulator.
    
 0.914
rps27a
Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]
   
 0.912
uba52
ubiquitin-60S ribosomal protein L40 isoform X1.
    
  0.901
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.890
ripk1
Receptor-interacting serine/threonine-protein kinase 1 isoform X1.
    
 0.838
rnf31
E3 ubiquitin-protein ligase RNF31.
    
 0.828
LOC108280771
Uncharacterized protein LOC108280771.
    
 0.828
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.
   
 
 0.789
ikbkb
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.
   
 0.756
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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