STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC105005930Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)    
Predicted Functional Partners:
ube2v2
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.983
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.974
ENSELUP00000003468
Ubiquitin-like domain-containing protein.
   
 0.972
rps27a
Ribosomal protein S27a.
   
 0.970
LOC105024213
Si:ch211-212o1.2.
   
 0.969
LOC105022328-2
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.969
LOC105016719
Ubiquitin-conjugating enzyme E2 variant 1.
   
 0.960
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.957
hltf
Helicase-like transcription factor.
    
 0.944
LOC105024444
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.913
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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