STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSELUP00000001351TIR domain-containing protein; Belongs to the Toll-like receptor family. (851 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.747
Unc93b1
Unc-93 homolog B1, TLR signaling regulator.
    
 0.661
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.628
ly86
Lymphocyte antigen 86.
   
 0.560
ripk1
Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.
    
 0.547
irak1
Interleukin-1 receptor-associated kinase 1.
    
 0.470
tirap
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.
   
 0.459
LOC105026239
Interferon regulatory factor 3.
    
 0.455
LOC105018625
Uncharacterized protein.
    
 0.446
tmed7
GOLD domain-containing protein.
    
 0.446
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
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