STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (592 aa)    
Predicted Functional Partners:
atm
Non-specific serine/threonine protein kinase.
    
 0.661
ENSELUP00000014319
Uncharacterized protein.
    
 0.636
LOC105008589
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.636
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.610
LOC105012971
WD_REPEATS_REGION domain-containing protein.
   
 
 0.610
mdm2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
    
 0.556
rps27a
Ribosomal protein S27a.
   
  0.483
Pin1
WW domain-containing protein.
    
 0.472
lin52
Uncharacterized protein.
    
 0.471
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.441
Your Current Organism:
Esox lucius
NCBI taxonomy Id: 8010
Other names: E. lucius, northern pike
Server load: low (30%) [HD]