node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSELUP00000003468 | ENSELUP00000004765 | ENSELUP00000003468 | ENSELUP00000004765 | Ubiquitin-like domain-containing protein. | HECT domain-containing protein. | 0.548 |
ENSELUP00000003468 | ENSELUP00000031806 | ENSELUP00000003468 | ENSELUP00000031806 | Ubiquitin-like domain-containing protein. | HECT domain-containing protein. | 0.548 |
ENSELUP00000003468 | ENSELUP00000031810 | ENSELUP00000003468 | ENSELUP00000031810 | Ubiquitin-like domain-containing protein. | Uncharacterized protein. | 0.548 |
ENSELUP00000003468 | LOC105011558 | ENSELUP00000003468 | ENSELUP00000018796 | Ubiquitin-like domain-containing protein. | Protein inhibitor of activated STAT, 4a. | 0.554 |
ENSELUP00000003468 | LOC114838787 | ENSELUP00000003468 | ENSELUP00000000122 | Ubiquitin-like domain-containing protein. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.965 |
ENSELUP00000003468 | rnf8 | ENSELUP00000003468 | ENSELUP00000013024 | Ubiquitin-like domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.954 |
ENSELUP00000004765 | ENSELUP00000003468 | ENSELUP00000004765 | ENSELUP00000003468 | HECT domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.548 |
ENSELUP00000004765 | ENSELUP00000031810 | ENSELUP00000004765 | ENSELUP00000031810 | HECT domain-containing protein. | Uncharacterized protein. | 0.683 |
ENSELUP00000004765 | LOC105011558 | ENSELUP00000004765 | ENSELUP00000018796 | HECT domain-containing protein. | Protein inhibitor of activated STAT, 4a. | 0.565 |
ENSELUP00000004765 | LOC105016384 | ENSELUP00000004765 | ENSELUP00000006955 | HECT domain-containing protein. | RAN binding protein 2. | 0.593 |
ENSELUP00000004765 | LOC114838787 | ENSELUP00000004765 | ENSELUP00000000122 | HECT domain-containing protein. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.546 |
ENSELUP00000004765 | ND4 | ENSELUP00000004765 | ENSELUP00000000011 | HECT domain-containing protein. | NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.526 |
ENSELUP00000004765 | neurl4 | ENSELUP00000004765 | ENSELUP00000020785 | HECT domain-containing protein. | Neuralized E3 ubiquitin protein ligase 4. | 0.525 |
ENSELUP00000004765 | rnf8 | ENSELUP00000004765 | ENSELUP00000013024 | HECT domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.685 |
ENSELUP00000004765 | zfand4 | ENSELUP00000004765 | ENSELUP00000024140 | HECT domain-containing protein. | Zinc finger, AN1-type domain 4. | 0.529 |
ENSELUP00000031806 | ENSELUP00000003468 | ENSELUP00000031806 | ENSELUP00000003468 | HECT domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.548 |
ENSELUP00000031806 | ENSELUP00000031810 | ENSELUP00000031806 | ENSELUP00000031810 | HECT domain-containing protein. | Uncharacterized protein. | 0.930 |
ENSELUP00000031806 | LOC105011558 | ENSELUP00000031806 | ENSELUP00000018796 | HECT domain-containing protein. | Protein inhibitor of activated STAT, 4a. | 0.565 |
ENSELUP00000031806 | LOC105016384 | ENSELUP00000031806 | ENSELUP00000006955 | HECT domain-containing protein. | RAN binding protein 2. | 0.593 |
ENSELUP00000031806 | LOC114838787 | ENSELUP00000031806 | ENSELUP00000000122 | HECT domain-containing protein. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.546 |