A0A060VRV1 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A060VRV1

Uncharacterized protein. (240 aa)

Predicted Functional Partners:

A0A060W4K3

0.837

A0A060WVB5

0.837

A0A060X2M3

0.837

A0A060VM37

0.826

A0A060VY01

0.826

A0A060VTS9

0.817

A0A060X9G7

0.816

A0A060Y5X6

0.813

A0A060YBK2

0.813

A0A060YCS8

0.813

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VM37	A0A060VRV1	Uncharacterized protein.	Uncharacterized protein.	0.826
A0A060VRV1	A0A060VM37	Uncharacterized protein.	Uncharacterized protein.	0.826
A0A060VRV1	A0A060VTS9	Uncharacterized protein.	Uncharacterized protein.	0.817
A0A060VRV1	A0A060VY01	Uncharacterized protein.	Uncharacterized protein.	0.826
A0A060VRV1	A0A060W4K3	Uncharacterized protein.	Uncharacterized protein.	0.837
A0A060VRV1	A0A060WVB5	Uncharacterized protein.	Uncharacterized protein.	0.837
A0A060VRV1	A0A060X2M3	Uncharacterized protein.	Uncharacterized protein.	0.837
A0A060VRV1	A0A060X9G7	Uncharacterized protein.	Uncharacterized protein.	0.816
A0A060VRV1	A0A060Y5X6	Uncharacterized protein.	Uncharacterized protein.	0.813
A0A060VRV1	A0A060YBK2	Uncharacterized protein.	I/LWEQ domain-containing protein.	0.813
A0A060VRV1	A0A060YCS8	Uncharacterized protein.	Uncharacterized protein.	0.813
A0A060VTS9	A0A060VRV1	Uncharacterized protein.	Uncharacterized protein.	0.817
A0A060VTS9	A0A060W4K3	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A060VTS9	A0A060WVB5	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A060VTS9	A0A060X2M3	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A060VY01	A0A060VRV1	Uncharacterized protein.	Uncharacterized protein.	0.826
A0A060W4K3	A0A060VRV1	Uncharacterized protein.	Uncharacterized protein.	0.837
A0A060W4K3	A0A060VTS9	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A060W4K3	A0A060X9G7	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A060WVB5	A0A060VRV1	Uncharacterized protein.	Uncharacterized protein.	0.837

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.776

expected number of edges:

13

PPI enrichment p-value:

0.000137

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006596

Polyamine biosynthetic process

6 of 25

3.01

6.95

1.07e-13

GO:0006591

Ornithine metabolic process

5 of 14

3.18

6.26

3.26e-12

GO:0006525

Arginine metabolic process

5 of 20

3.02

5.9

1.19e-11

GO:1901605

Alpha-amino acid metabolic process

9 of 321

2.07

5.54

1.97e-14

GO:0009446

Putrescine biosynthetic process

4 of 8

3.32

5.14

4.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016813

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

5 of 16

3.12

5.87

1.61e-11

GO:0004053

Arginase activity

3 of 3

3.63

3.62

3.05e-07

GO:0008783

Agmatinase activity

2 of 2

3.63

2.01

0.00024

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

2 of 4

3.32

1.89

0.00039

GO:0004586

Ornithine decarboxylase activity

2 of 5

3.23

1.88

0.00041

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:3761021

(1986) Urea cycle activity and arginine formation in rainbow trout (Salmo gairdneri)

3 of 3

3.63

3.43

6.78e-07

PMID:29238889

(2018) Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss).

3 of 3

3.63

3.43

6.78e-07

PMID:26600157

(2015) Widespread Natural Occurrence of Hydroxyurea in Animals.

3 of 3

3.63

3.43

6.78e-07

PMID:34578212

(2021) Intestinal Transcriptomic and Histologic Profiling Reveals Tissue Repair Mechanisms Underlying Resistance to the Parasite Ceratonova shasta.

3 of 5

3.4

3.42

6.78e-07

PMID:34201988

(2021) Post-Prandial Amino Acid Changes in Gilthead Sea Bream.

3 of 5

3.4

3.42

6.78e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:55228

Arginase, and Agmatinase activity

5 of 5

3.63

6.76

5.91e-13

CL:57371

Polyamine biosynthetic process, and UDP-N-acetylglucosamine biosynthetic process

3 of 34

2.57

2.19

8.74e-05

CL:60604

Mixed, incl. S-methyl-5-thioadenosine phosphorylase activity, and Spermine synthase, animal

2 of 6

3.15

1.57

0.0015

CL:57417

Ornithine decarboxylase, and Ornithine decarboxylase antizyme

2 of 6

3.15

1.57

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

9 of 199

2.28

7.41

6.59e-18

map00270

Cysteine and methionine metabolism

4 of 157

2.03

2.64

2.98e-06

map00220

Arginine biosynthesis

3 of 73

2.24

2.3

3.42e-05

map00480

Glutathione metabolism

3 of 194

1.81

1.59

0.00048

map01230

Biosynthesis of amino acids

3 of 278

1.66

1.35

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-351143

Agmatine biosynthesis

4 of 4

3.63

5.54

1.00e-10

MAP-71291

Metabolism of amino acids and derivatives

11 of 664

1.84

5.28

9.44e-18

MAP-351202

Metabolism of polyamines

6 of 153

2.22

4.43

3.73e-10

MAP-70635

Urea cycle

3 of 11

3.06

3.25

1.21e-06

MAP-1237112

Methionine salvage pathway

2 of 6

3.15

1.88

0.00040

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0835

Urea cycle

3 of 3

3.63

3.98

6.89e-08

KW-0056

Arginine metabolism

3 of 3

3.63

3.98

6.89e-08

KW-0620

Polyamine biosynthesis

2 of 4

3.32

2.25

8.65e-05

KW-0464

Manganese

3 of 75

2.23

2.1

8.65e-05

KW-0378

Hydrolase

4 of 950

1.25

0.94

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00491

Arginase family

4 of 4

3.63

5.2

4.09e-10

PF02784

Pyridoxal-dependent decarboxylase, pyridoxal binding domain

2 of 5

3.23

1.52

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020855

Ureohydrolase, manganese-binding site

4 of 4

3.63

4.95

1.19e-09

IPR006035

Ureohydrolase

4 of 4

3.63

4.95

1.19e-09

IPR023696

Ureohydrolase domain superfamily

4 of 30

2.75

3.54

2.61e-07

IPR014033

Arginase

3 of 3

3.63

3.5

4.92e-07

IPR022657

Orn/DAP/Arg decarboxylase 2, conserved site

2 of 3

3.45

1.67

0.0010

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About