A0A060W7M9 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

A0A060W7M9

Uncharacterized protein. (302 aa)

Predicted Functional Partners:

A0A060Y7P3

0.591

A0A060Z1S8

0.562

A0A060XUD7

0.542

A0A060XI98

0.514

A0A060WQQ3

0.506

A0A060VSX3

0.459

A0A060VZA8

0.459

A0A060VZS9

0.459

A0A060WYY6

0.459

A0A060XP33

0.459

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VSX3	A0A060VZA8	Uncharacterized protein.	Uncharacterized protein.	0.990
A0A060VSX3	A0A060VZS9	Uncharacterized protein.	Ion_trans domain-containing protein.	0.983
A0A060VSX3	A0A060W7M9	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A060VSX3	A0A060XI98	Uncharacterized protein.	Uncharacterized protein.	0.906
A0A060VSX3	A0A060XP33	Uncharacterized protein.	Uncharacterized protein.	0.991
A0A060VSX3	A0A060XUD7	Uncharacterized protein.	Uncharacterized protein.	0.980
A0A060VSX3	A0A060Y7P3	Uncharacterized protein.	PDZ domain-containing protein.	0.909
A0A060VSX3	A0A060Z1S8	Uncharacterized protein.	Uncharacterized protein.	0.926
A0A060VZA8	A0A060VSX3	Uncharacterized protein.	Uncharacterized protein.	0.990
A0A060VZA8	A0A060VZS9	Uncharacterized protein.	Ion_trans domain-containing protein.	0.472
A0A060VZA8	A0A060W7M9	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A060VZA8	A0A060WYY6	Uncharacterized protein.	Uncharacterized protein.	0.975
A0A060VZA8	A0A060XI98	Uncharacterized protein.	Uncharacterized protein.	0.814
A0A060VZA8	A0A060XP33	Uncharacterized protein.	Uncharacterized protein.	0.977
A0A060VZA8	A0A060XUD7	Uncharacterized protein.	Uncharacterized protein.	0.994
A0A060VZA8	A0A060Y7P3	Uncharacterized protein.	PDZ domain-containing protein.	0.941
A0A060VZA8	A0A060Z1S8	Uncharacterized protein.	Uncharacterized protein.	0.938
A0A060VZS9	A0A060VSX3	Ion_trans domain-containing protein.	Uncharacterized protein.	0.983
A0A060VZS9	A0A060VZA8	Ion_trans domain-containing protein.	Uncharacterized protein.	0.472
A0A060VZS9	A0A060W7M9	Ion_trans domain-containing protein.	Uncharacterized protein.	0.459

page 1 of 5

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.406

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042773

ATP synthesis coupled electron transport

8 of 35

2.59

7.83

1.21e-16

GO:0022900

Electron transport chain

9 of 71

2.33

7.26

6.19e-17

GO:0019646

Aerobic electron transport chain

7 of 31

2.58

6.88

1.64e-14

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

7 of 32

2.57

6.85

1.71e-14

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

4 of 9

2.88

4.21

1.59e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 40

2.47

6.2

2.16e-13

GO:0009055

Electron transfer activity

7 of 65

2.26

5.36

2.52e-12

GO:0008121

Ubiquinol-cytochrome-c reductase activity

3 of 8

2.8

2.84

5.95e-06

GO:0015078

Proton transmembrane transporter activity

5 of 101

1.93

2.75

7.97e-07

GO:0022853

Active ion transmembrane transporter activity

5 of 150

1.75

2.28

4.52e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

10 of 58

2.47

9.39

1.87e-21

GO:0070069

Cytochrome complex

6 of 16

2.8

6.93

5.47e-14

GO:0005746

Mitochondrial respirasome

7 of 46

2.41

6.4

3.86e-14

GO:0098803

Respiratory chain complex

7 of 47

2.4

6.38

3.88e-14

GO:0098800

Inner mitochondrial membrane protein complex

7 of 83

2.16

5.25

1.08e-12

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22310

Cytochrome complex, and Peptidase M16, zinc-binding site

9 of 20

2.88

10.62

1.90e-21

CL:22312

Cytochrome complex

6 of 12

2.93

7.22

2.41e-14

CL:22338

Mitochondrial electron transport, ubiquinol to cytochrome c

3 of 5

3.01

3.22

1.34e-06

CL:22315

Mitochondrial respiratory chain complex IV

3 of 6

2.93

3.12

1.90e-06

CL:5987

NADH dehydrogenase complex

2 of 20

2.23

1.07

0.0102

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 158

2.07

7.29

3.55e-21

map01100

Metabolic pathways

11 of 4972

0.58

0.51

3.58e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 70

2.43

10.13

4.69e-24

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 81

2.36

9.67

1.04e-23

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 201

1.97

6.36

9.64e-20

MAP-9707564

Cytoprotection by HMOX1

3 of 28

2.26

2.03

0.00013

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 39

2.12

1.83

0.00027

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

4 of 9

2.88

4.4

6.80e-09

GOCC:0005743

Mitochondrial inner membrane

8 of 185

1.87

4.13

9.14e-12

GOCC:0005746

Mitochondrial respirasome

4 of 18

2.58

3.84

4.85e-08

GOCC:0098803

Respiratory chain complex

4 of 22

2.49

3.68

8.26e-08

GOCC:0098798

Mitochondrial protein complex

7 of 187

1.8

3.46

7.57e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 8

2.63

1.35

0.0035

KW-0830

Ubiquinone

2 of 17

2.3

1.18

0.0066

KW-0999

Mitochondrion inner membrane

2 of 40

1.93

0.93

0.0165

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05193

Peptidase M16 inactive domain

3 of 6

2.93

2.64

1.52e-05

PF00675

Insulinase (Peptidase family M16)

3 of 6

2.93

2.64

1.52e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011765

Peptidase M16, N-terminal

3 of 6

2.93

2.41

4.09e-05

IPR011249

Metalloenzyme, LuxS/M16 peptidase-like

3 of 6

2.93

2.41

4.09e-05

IPR007863

Peptidase M16, C-terminal

3 of 6

2.93

2.41

4.09e-05

IPR001431

Peptidase M16, zinc-binding site

2 of 2

3.23

1.57

0.0015

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