A0A060WDB6 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A060WDB6

Uncharacterized protein. (278 aa)

Predicted Functional Partners:

A0A060WBM1

0.724

A0A060XBA3

0.724

A0A060XHK0

0.724

A0A060YYY9

0.724

A0A060VW08

0.528

A0A060W1S6

0.528

A0A060XQQ5

0.528

A0A060VN99

0.521

A0A060VV18

0.521

A0A060WUX9

0.521

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VN99	A0A060VW08	Uncharacterized protein.	Uncharacterized protein.	0.446
A0A060VN99	A0A060W1S6	Uncharacterized protein.	Uncharacterized protein.	0.441
A0A060VN99	A0A060WBM1	Uncharacterized protein.	VPS9 domain-containing protein.	0.496
A0A060VN99	A0A060WDB6	Uncharacterized protein.	Uncharacterized protein.	0.521
A0A060VN99	A0A060XBA3	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VN99	A0A060XHK0	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VN99	A0A060XQQ5	Uncharacterized protein.	Uncharacterized protein.	0.442
A0A060VN99	A0A060YYY9	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VV18	A0A060VW08	Uncharacterized protein.	Uncharacterized protein.	0.463
A0A060VV18	A0A060W1S6	Uncharacterized protein.	Uncharacterized protein.	0.462
A0A060VV18	A0A060WBM1	Uncharacterized protein.	VPS9 domain-containing protein.	0.496
A0A060VV18	A0A060WDB6	Uncharacterized protein.	Uncharacterized protein.	0.521
A0A060VV18	A0A060XBA3	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VV18	A0A060XHK0	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VV18	A0A060XQQ5	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A060VV18	A0A060YYY9	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A060VW08	A0A060VN99	Uncharacterized protein.	Uncharacterized protein.	0.446
A0A060VW08	A0A060VV18	Uncharacterized protein.	Uncharacterized protein.	0.463
A0A060VW08	A0A060WBM1	Uncharacterized protein.	VPS9 domain-containing protein.	0.496
A0A060VW08	A0A060WDB6	Uncharacterized protein.	Uncharacterized protein.	0.528

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

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