A0A060WEU8 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A060WEU8

Uncharacterized protein. (104 aa)

Predicted Functional Partners:

A0A060YR87

0.937

A0A060X668

0.916

A0A060XFM2

0.913

A0A060XTN5

0.913

A0A060YRG9

0.907

A0A060YSA7

0.907

A0A060YV80

0.907

A0A060XAI2

0.903

A0A060WWD9

0.898

A0A060X309

0.898

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060WEU8	A0A060WWD9	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.898
A0A060WEU8	A0A060X309	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.898
A0A060WEU8	A0A060X668	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.916
A0A060WEU8	A0A060XAI2	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.903
A0A060WEU8	A0A060XFM2	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.913
A0A060WEU8	A0A060XTN5	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.913
A0A060WEU8	A0A060YR87	Uncharacterized protein.	Integrin beta.	0.937
A0A060WEU8	A0A060YRG9	Uncharacterized protein.	Fibronectin type-I domain-containing protein.	0.907
A0A060WEU8	A0A060YSA7	Uncharacterized protein.	Uncharacterized protein.	0.907
A0A060WEU8	A0A060YV80	Uncharacterized protein.	Uncharacterized protein.	0.907
A0A060WWD9	A0A060WEU8	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.898
A0A060WWD9	A0A060X668	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.759
A0A060WWD9	A0A060XAI2	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.896
A0A060WWD9	A0A060XFM2	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.760
A0A060WWD9	A0A060XTN5	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.759
A0A060WWD9	A0A060YR87	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta.	0.728
A0A060WWD9	A0A060YRG9	Integrin beta; Belongs to the integrin beta chain family.	Fibronectin type-I domain-containing protein.	0.938
A0A060WWD9	A0A060YSA7	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.938
A0A060WWD9	A0A060YV80	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.938
A0A060X309	A0A060WEU8	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.898

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.804

expected number of edges:

12

PPI enrichment p-value:

2.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

7 of 82

2.53

6.47

8.42e-14

GO:0019682

glyceraldehyde-3-phosphate metabolic process

4 of 8

3.3

5.04

6.78e-10

GO:0005975

Carbohydrate metabolic process

8 of 308

2.01

4.78

1.67e-12

GO:0006096

Glycolytic process

4 of 21

2.88

4.28

1.14e-08

GO:0019637

Organophosphate metabolic process

10 of 677

1.77

4.26

4.29e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

5 of 211

1.97

2.62

2.42e-06

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

4 of 144

2.04

2.25

2.58e-05

GO:0052591

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

2 of 2

3.6

2.11

0.00016

GO:0008929

Methylglyoxal synthase activity

2 of 2

3.6

2.11

0.00016

GO:0004807

Triose-phosphate isomerase activity

2 of 2

3.6

2.11

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.7

2.12e-07

GO:0005829

Cytosol

7 of 1756

1.2

1.32

2.25e-05

GO:0005739

Mitochondrion

4 of 1201

1.12

0.64

0.0243

GO:0005737

Cytoplasm

11 of 10623

0.61

0.54

5.51e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:9211740

(1997) An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks.

2 of 2

3.6

1.5

0.0020

PMID:35193395

(2022) Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates.

2 of 3

3.42

1.5

0.0020

PMID:34769888

(2021) Prevalence, Molecular Characterization and Antimicrobial Susceptibility of Clostridioides difficile Isolated from Pig Carcasses and Pork Products in Central Italy.

2 of 2

3.6

1.5

0.0020

PMID:34093163

(2021) Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.

2 of 2

3.6

1.5

0.0020

PMID:31547548

(2019) Enzymes from Marine Polar Regions and Their Biotechnological Applications.

2 of 4

3.3

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11044

Glycolysis, and Transketolase or transaldolase activity

5 of 12

3.22

6.02

9.38e-12

CL:11045

Glycolysis, and Phosphopyruvate hydratase complex

4 of 7

3.35

5.02

7.76e-10

CL:3319

Glycerol catabolic process, and Ethanolamine metabolic process

3 of 6

3.3

3.52

4.29e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu00051

Fructose and mannose metabolism

5 of 22

2.95

6.14

3.52e-12

aqu01200

Carbon metabolism

6 of 106

2.35

5.35

7.15e-12

aqu01230

Biosynthesis of amino acids

5 of 57

2.54

5.11

9.37e-11

aqu00010

Glycolysis / Gluconeogenesis

4 of 38

2.62

4.26

7.56e-09

aqu00030

Pentose phosphate pathway

3 of 22

2.73

3.32

6.76e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 20

2.9

4.29

1.16e-08

MAP-1483166

Synthesis of PA

4 of 29

2.74

4.08

2.23e-08

MAP-70263

Gluconeogenesis

4 of 55

2.46

3.48

1.98e-07

MAP-71387

Metabolism of carbohydrates

6 of 287

1.92

3.35

1.32e-08

MAP-70326

Glucose metabolism

4 of 65

2.39

3.34

3.13e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.81

1.34e-07

GOCC:0005737

Cytoplasm

11 of 5405

0.91

1.01

1.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

4 of 12

3.12

4.91

1.03e-09

KW-0312

Gluconeogenesis

2 of 3

3.42

2.29

7.46e-05

KW-0704

Schiff base

2 of 5

3.2

2.21

0.00010

KW-0456

Lyase

2 of 47

2.23

1.26

0.0044

KW-0413

Isomerase

2 of 57

2.14

1.21

0.0051

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00274

Fructose-bisphosphate aldolase class-I

2 of 2

3.6

1.79

0.00060

PF00121

Triosephosphate isomerase

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 58

2.44

2.76

5.64e-06

IPR035990

Triosephosphate isomerase superfamily

2 of 2

3.6

1.72

0.00080

IPR029768

Fructose-bisphosphate aldolase class-I active site

2 of 2

3.6

1.72

0.00080

IPR000741

Fructose-bisphosphate aldolase, class-I

2 of 2

3.6

1.72

0.00080

IPR000652

Triosephosphate isomerase

2 of 2

3.6

1.72

0.00080

(more ...)

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