A0A060X697 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A060X697

Uncharacterized protein. (172 aa)

Predicted Functional Partners:

A0A060W541

0.633

A0A060WMN6

0.633

A0A060WNP0

0.633

A0A060WAL0

0.627

A0A060XGM2

0.627

A0A060Y077

0.627

A0A060YHY3

0.619

A0A060WIB1

0.586

A0A060WRH6

0.586

A0A060VZW7

0.579

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VZW7	A0A060W541	Uncharacterized protein.	Amino acid transporter.	0.755
A0A060VZW7	A0A060WAL0	Uncharacterized protein.	Amino acid transporter.	0.748
A0A060VZW7	A0A060WIB1	Uncharacterized protein.	Amino acid transporter.	0.580
A0A060VZW7	A0A060WMN6	Uncharacterized protein.	Amino acid transporter.	0.763
A0A060VZW7	A0A060WNP0	Uncharacterized protein.	Amino acid transporter.	0.756
A0A060VZW7	A0A060WRH6	Uncharacterized protein.	Amino acid transporter.	0.579
A0A060VZW7	A0A060X697	Uncharacterized protein.	Uncharacterized protein.	0.579
A0A060VZW7	A0A060XGM2	Uncharacterized protein.	Amino acid transporter.	0.747
A0A060VZW7	A0A060Y077	Uncharacterized protein.	Amino acid transporter.	0.750
A0A060VZW7	A0A060YHY3	Uncharacterized protein.	Amino acid transporter.	0.581
A0A060W541	A0A060VZW7	Amino acid transporter.	Uncharacterized protein.	0.755
A0A060W541	A0A060WAL0	Amino acid transporter.	Amino acid transporter.	0.800
A0A060W541	A0A060WIB1	Amino acid transporter.	Amino acid transporter.	0.762
A0A060W541	A0A060WRH6	Amino acid transporter.	Amino acid transporter.	0.760
A0A060W541	A0A060X697	Amino acid transporter.	Uncharacterized protein.	0.633
A0A060W541	A0A060XGM2	Amino acid transporter.	Amino acid transporter.	0.799
A0A060W541	A0A060Y077	Amino acid transporter.	Amino acid transporter.	0.800
A0A060W541	A0A060YHY3	Amino acid transporter.	Amino acid transporter.	0.762
A0A060WAL0	A0A060VZW7	Amino acid transporter.	Uncharacterized protein.	0.748
A0A060WAL0	A0A060W541	Amino acid transporter.	Amino acid transporter.	0.800

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.879

expected number of edges:

42

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

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