A0A060Y1H9 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A060Y1H9

Uncharacterized protein. (627 aa)

Predicted Functional Partners:

A0A060WEM0

0.670

A0A060WK06

0.670

A0A060XQF2

0.670

A0A060Y8M9

0.670

A0A060YCU5

0.670

A0A060YDX3

0.670

A0A060YZU6

0.670

A0A060WH11

0.610

A0A060VU80

0.605

A0A060WRP2

0.605

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VU80	A0A060WRP2	Uncharacterized protein.	FAD-binding FR-type domain-containing protein.	0.435
A0A060VU80	A0A060Y1H9	Uncharacterized protein.	Uncharacterized protein.	0.605
A0A060WEM0	A0A060WH11	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WEM0	A0A060Y1H9	Uncharacterized protein.	Uncharacterized protein.	0.670
A0A060WH11	A0A060WEM0	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WH11	A0A060WK06	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WH11	A0A060XQF2	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WH11	A0A060Y1H9	Uncharacterized protein.	Uncharacterized protein.	0.610
A0A060WH11	A0A060Y8M9	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.851
A0A060WH11	A0A060YCU5	Uncharacterized protein.	SET domain-containing protein.	0.851
A0A060WH11	A0A060YDX3	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WH11	A0A060YZU6	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WK06	A0A060WH11	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060WK06	A0A060Y1H9	Uncharacterized protein.	Uncharacterized protein.	0.670
A0A060WRP2	A0A060VU80	FAD-binding FR-type domain-containing protein.	Uncharacterized protein.	0.435
A0A060WRP2	A0A060Y1H9	FAD-binding FR-type domain-containing protein.	Uncharacterized protein.	0.605
A0A060XQF2	A0A060WH11	Uncharacterized protein.	Uncharacterized protein.	0.851
A0A060XQF2	A0A060Y1H9	Uncharacterized protein.	Uncharacterized protein.	0.670
A0A060Y1H9	A0A060VU80	Uncharacterized protein.	Uncharacterized protein.	0.605
A0A060Y1H9	A0A060WEM0	Uncharacterized protein.	Uncharacterized protein.	0.670

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.864

expected number of edges:

11

PPI enrichment p-value:

8.6e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006606

Protein import into nucleus

4 of 34

2.26

2.61

7.67e-06

GO:0006913

Nucleocytoplasmic transport

5 of 86

1.96

2.45

5.86e-06

GO:0031053

Primary miRNA processing

2 of 6

2.71

1.49

0.0019

GO:0051168

Nuclear export

3 of 52

1.95

1.47

0.0012

GO:0046907

Intracellular transport

6 of 440

1.33

1.41

7.16e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140142

Nucleocytoplasmic carrier activity

3 of 20

2.37

1.73

0.00057

GO:0000339

RNA cap binding

2 of 6

2.71

1.23

0.0057

GO:0061608

Nuclear import signal receptor activity

2 of 11

2.45

1.09

0.0101

GO:0008139

Nuclear localization sequence binding

2 of 10

2.49

1.09

0.0101

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0005845

mRNA cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0000808

Origin recognition complex

2 of 5

2.79

1.59

0.0013

GO:0005634

Nucleus

10 of 2571

0.78

0.72

4.14e-05

GO:0005694

Chromosome

3 of 263

1.25

0.6

0.0443

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4425

Nuclear localization sequence binding, and CAS/CSE protein, C-terminus

3 of 6

2.89

2.69

1.19e-05

CL:4287

Mixed, incl. Nuclear Envelope Breakdown, and Nucleocytoplasmic carrier activity

5 of 80

1.99

2.62

2.63e-06

CL:9082

mRNA cap binding complex, and Initiation factor 4G

2 of 5

2.79

1.36

0.0034

CL:6807

CDC6 association with the ORC:origin complex

2 of 6

2.71

1.33

0.0038

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

5 of 207

1.57

1.88

1.71e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68616

Assembly of the ORC complex at the origin of replication

3 of 16

2.46

2.03

0.00016

MAP-68867

Assembly of the pre-replicative complex

3 of 47

2.0

1.57

0.00081

MAP-68689

CDC6 association with the ORC:origin complex

2 of 7

2.65

1.44

0.0023

MAP-69278

Cell Cycle, Mitotic

5 of 316

1.39

1.3

0.00040

MAP-69002

DNA Replication Pre-Initiation

3 of 78

1.78

1.29

0.0023

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.01

1.34

0.0038

GOCC:0005664

Nuclear origin of replication recognition complex

2 of 5

2.79

1.32

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 321

1.29

0.86

0.0084

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016024

Armadillo-type fold

4 of 238

1.42

0.64

0.0447

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00913

Importin-beta N-terminal domain

2 of 10

2.49

1.12

0.0090

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