A0A060Z0Q9 protein (Oncorhynchus mykiss) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

A0A060Z0Q9

Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (114 aa)

Predicted Functional Partners:

A0A060ZAK0

0.894

A0A060WHA4

0.873

A0A060YP44

0.870

A0A060Z6I0

0.870

A0A060XAN6

0.866

A0A060XVD9

0.839

A0A060WSN3

0.831

A0A060YV89

0.831

Q7SZV5_ONCMY

0.803

A0A060W7V1

0.758

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A060W7V1	A0A060WHA4	A0A060W7V1	A0A060WHA4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Motilin_assoc domain-containing protein.	0.696
A0A060W7V1	A0A060WSN3	A0A060W7V1	A0A060WSN3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Somatostatin domain-containing protein.	0.637
A0A060W7V1	A0A060XAN6	A0A060W7V1	A0A060XAN6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the NPY family.	0.667
A0A060W7V1	A0A060XVD9	A0A060W7V1	A0A060XVD9	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.839
A0A060W7V1	A0A060YP44	A0A060W7V1	A0A060YP44	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.716
A0A060W7V1	A0A060YV89	A0A060W7V1	A0A060YV89	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Somatostatin domain-containing protein.	0.637
A0A060W7V1	A0A060Z0Q9	A0A060W7V1	A0A060Z0Q9	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.758
A0A060W7V1	A0A060Z6I0	A0A060W7V1	A0A060Z6I0	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.716
A0A060W7V1	A0A060ZAK0	A0A060W7V1	A0A060ZAK0	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	END domain-containing protein.	0.751
A0A060W7V1	Q7SZV5_ONCMY	A0A060W7V1	Q7SZV5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Neuropeptide Y.	0.736
A0A060WHA4	A0A060W7V1	A0A060WHA4	A0A060W7V1	Motilin_assoc domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.696
A0A060WHA4	A0A060WSN3	A0A060WHA4	A0A060WSN3	Motilin_assoc domain-containing protein.	Somatostatin domain-containing protein.	0.506
A0A060WHA4	A0A060XAN6	A0A060WHA4	A0A060XAN6	Motilin_assoc domain-containing protein.	Uncharacterized protein; Belongs to the NPY family.	0.527
A0A060WHA4	A0A060YP44	A0A060WHA4	A0A060YP44	Motilin_assoc domain-containing protein.	Uncharacterized protein.	0.630
A0A060WHA4	A0A060YV89	A0A060WHA4	A0A060YV89	Motilin_assoc domain-containing protein.	Somatostatin domain-containing protein.	0.506
A0A060WHA4	A0A060Z0Q9	A0A060WHA4	A0A060Z0Q9	Motilin_assoc domain-containing protein.	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.873
A0A060WHA4	A0A060Z6I0	A0A060WHA4	A0A060Z6I0	Motilin_assoc domain-containing protein.	Uncharacterized protein.	0.630
A0A060WHA4	Q7SZV5_ONCMY	A0A060WHA4	Q7SZV5	Motilin_assoc domain-containing protein.	Neuropeptide Y.	0.531
A0A060WSN3	A0A060W7V1	A0A060WSN3	A0A060W7V1	Somatostatin domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.637
A0A060WSN3	A0A060WHA4	A0A060WSN3	A0A060WHA4	Somatostatin domain-containing protein.	Motilin_assoc domain-containing protein.	0.506

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.941

expected number of edges:

20

PPI enrichment p-value:

0.123

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903298

Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

4 of 4

3.98

5.92

2.26e-11

GO:0071456

Cellular response to hypoxia

4 of 608

1.8

1.89

7.88e-05

GO:0033554

Cellular response to stress

5 of 3767

1.1

0.84

0.0035

GO:0070887

Cellular response to chemical stimulus

5 of 6264

0.88

0.5

0.0356

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

5 of 220

2.34

3.66

5.39e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034663

Endoplasmic reticulum chaperone complex

4 of 31

3.09

4.75

1.97e-09

GO:0005788

Endoplasmic reticulum lumen

5 of 140

2.53

4.48

1.97e-09

GO:0099503

Secretory vesicle

4 of 235

2.21

2.8

2.61e-06

GO:0000325

Plant-type vacuole

4 of 1274

1.48

1.3

0.00077

GO:0070013

Intracellular organelle lumen

6 of 3685

1.19

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95099

Riboflavin kinase domain superfamily, and FAD biosynthetic process

4 of 15

3.41

4.64

3.88e-09

CL:3745

Mixed, incl. Heat shock protein 70 family, and Heat shock protein Hsp90 family

5 of 117

2.61

4.33

5.31e-09

CL:3776

Mixed, incl. Heat shock protein 70 family, and Heat shock protein Hsp90, conserved site

3 of 34

2.93

2.73

1.02e-05

CL:3954

Mixed, incl. Regulation of intrinsic apoptotic signaling pathway, and Nucleotide exchange factor Fes1

2 of 5

3.58

2.13

0.00015

CL:95101

Riboflavin kinase domain, bacterial/eukaryotic, and FAD biosynthetic process

2 of 8

3.38

1.96

0.00030

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00740

Riboflavin metabolism

4 of 276

2.14

2.89

1.26e-06

map04141

Protein processing in endoplasmic reticulum

6 of 1598

1.55

2.18

8.52e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-381070

IRE1alpha activates chaperones

5 of 37

3.11

6.23

3.22e-12

MAP-381119

Unfolded Protein Response (UPR)

5 of 91

2.72

5.22

1.16e-10

MAP-8953897

Cellular responses to stimuli

6 of 2435

1.37

1.6

1.78e-05

MAP-2262752

Cellular responses to stress

6 of 2406

1.38

1.6

1.78e-05

MAP-5653656

Vesicle-mediated transport

5 of 1735

1.44

1.52

9.24e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034663

Endoplasmic reticulum chaperone complex

5 of 41

3.07

5.96

9.86e-12

GOCC:0110165

Cellular anatomical entity

7 of 8339

0.9

0.7

0.0027

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13419

Haloacid dehalogenase-like hydrolase

3 of 49

2.77

2.3

6.15e-05

PF06723

MreB/Mbl protein

3 of 95

2.48

1.97

0.00021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 39

2.99

3.88

7.55e-08

IPR023465

Riboflavin kinase domain superfamily

3 of 6

3.68

3.6

3.38e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 76

2.7

3.47

3.38e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 73

2.72

3.47

3.38e-07

IPR018181

Heat shock protein 70, conserved site

4 of 92

2.62

3.4

4.05e-07

(more ...)

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