A0A060Z6U5 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A060Z6U5

Uncharacterized protein. (199 aa)

Predicted Functional Partners:

A0A060X3Y1

0.909

A0A060WR13

0.863

A0A060WQI9

0.862

A0A060Z8E9

0.860

A0A060XHA1

0.851

A0A060YFN8

0.851

A0A060Z493

0.851

A0A060VUH5

0.847

A0A060YK16

0.847

A0A060ZF19

0.847

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VUH5	A0A060WQI9	Cytochrome b5 heme-binding domain-containing protein.	Uncharacterized protein.	0.606
A0A060VUH5	A0A060WR13	Cytochrome b5 heme-binding domain-containing protein.	Choline dehydrogenase.	0.568
A0A060VUH5	A0A060X3Y1	Cytochrome b5 heme-binding domain-containing protein.	Carrier domain-containing protein.	0.530
A0A060VUH5	A0A060XHA1	Cytochrome b5 heme-binding domain-containing protein.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.942
A0A060VUH5	A0A060YFN8	Cytochrome b5 heme-binding domain-containing protein.	NAD_binding_1 domain-containing protein.	0.942
A0A060VUH5	A0A060Z493	Cytochrome b5 heme-binding domain-containing protein.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.942
A0A060VUH5	A0A060Z6U5	Cytochrome b5 heme-binding domain-containing protein.	Uncharacterized protein.	0.847
A0A060VUH5	A0A060Z8E9	Cytochrome b5 heme-binding domain-containing protein.	Uncharacterized protein.	0.942
A0A060WQI9	A0A060VUH5	Uncharacterized protein.	Cytochrome b5 heme-binding domain-containing protein.	0.606
A0A060WQI9	A0A060X3Y1	Uncharacterized protein.	Carrier domain-containing protein.	0.527
A0A060WQI9	A0A060Z6U5	Uncharacterized protein.	Uncharacterized protein.	0.862
A0A060WR13	A0A060VUH5	Choline dehydrogenase.	Cytochrome b5 heme-binding domain-containing protein.	0.568
A0A060WR13	A0A060X3Y1	Choline dehydrogenase.	Carrier domain-containing protein.	0.523
A0A060WR13	A0A060YK16	Choline dehydrogenase.	Uncharacterized protein.	0.793
A0A060WR13	A0A060Z6U5	Choline dehydrogenase.	Uncharacterized protein.	0.863
A0A060WR13	A0A060ZF19	Choline dehydrogenase.	Uncharacterized protein.	0.793
A0A060X3Y1	A0A060VUH5	Carrier domain-containing protein.	Cytochrome b5 heme-binding domain-containing protein.	0.530
A0A060X3Y1	A0A060WQI9	Carrier domain-containing protein.	Uncharacterized protein.	0.527
A0A060X3Y1	A0A060WR13	Carrier domain-containing protein.	Choline dehydrogenase.	0.523
A0A060X3Y1	A0A060XHA1	Carrier domain-containing protein.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.572

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007031

Peroxisome organization

11 of 24

2.76

12.45

3.02e-26

GO:0006625

Protein targeting to peroxisome

9 of 13

2.94

10.75

1.75e-21

GO:0015919

Peroxisomal membrane transport

9 of 15

2.88

10.62

1.84e-21

GO:0016558

Protein import into peroxisome matrix

7 of 11

2.91

8.03

5.18e-16

GO:0048137

Spermatocyte division

5 of 16

2.6

4.7

8.82e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000268

Peroxisome targeting sequence binding

3 of 3

3.1

2.63

1.71e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

10 of 25

2.71

10.96

3.22e-23

GO:0005777

Peroxisome

11 of 99

2.15

7.81

1.79e-21

GO:1990429

Peroxisomal importomer complex

3 of 3

3.1

3.24

1.28e-06

GO:0005779

Integral component of peroxisomal membrane

3 of 10

2.58

2.57

1.60e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21669930

(2011) A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders.

11 of 33

2.63

10.89

1.00e-23

PMID:21826223

(2011) Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.

9 of 20

2.76

9.2

6.34e-19

PMID:24263361

(2013) Peroxisomes take shape.

8 of 15

2.83

8.3

9.61e-17

PMID:20156962

(2010) Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation.

8 of 18

2.75

8.0

2.30e-16

PMID:33046344

(2021) Balancing the Opposing Principles That Govern Peroxisome Homeostasis.

8 of 22

2.66

7.64

6.88e-16

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3573

Peroxisome organization

11 of 17

2.91

13.68

6.67e-28

CL:3575

Protein targeting to peroxisome

10 of 12

3.02

12.91

1.19e-25

CL:3577

Protein import into peroxisome matrix

6 of 7

3.04

7.19

3.90e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dme04146

Peroxisome

11 of 90

2.19

8.29

2.19e-22

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DME-9603798

Class I peroxisomal membrane protein import

7 of 16

2.74

7.48

2.75e-15

DME-9609507

Protein localization

10 of 88

2.16

7.0

2.78e-18

DME-8866654

E3 ubiquitin ligases ubiquitinate target proteins

5 of 19

2.52

4.53

1.54e-09

DME-9033241

Peroxisomal protein import

6 of 44

2.24

4.49

3.29e-10

DME-1369062

ABC transporters in lipid homeostasis

2 of 20

2.1

0.84

0.0274

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

10 of 23

2.74

11.16

2.03e-23

GOCC:0005777

Peroxisome

11 of 91

2.19

8.1

9.37e-22

GOCC:1990429

Peroxisomal importomer complex

5 of 5

3.1

6.06

6.77e-12

GOCC:0005782

Peroxisomal matrix

3 of 4

2.98

3.07

2.45e-06

GOCC:0005779

Integral component of peroxisomal membrane

2 of 7

2.56

1.51

0.0017

Drosophila Phenotype (Monarch)

phenotype

description

count in network

strength

signal

false discovery rate

FBcv:0000431

Abnormal meiotic cell cycle

4 of 221

1.36

1.02

0.0033

FBcv:0000665

Abnormal body size

4 of 403

1.1

0.75

0.0084

FBcv:0000425

Increased cell death

4 of 554

0.96

0.58

0.0224

FBcv:0000357

Abnormal size

6 of 1213

0.8

0.56

0.0077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0576

Peroxisome

2 of 12

2.32

0.92

0.0205

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04757

Pex2 / Pex12 amino terminal region

2 of 3

2.93

1.18

0.0073

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006845

Pex, N-terminal

2 of 3

2.93

0.91

0.0229

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