A0A060Z7Q0 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A060Z7Q0

DHR-2 domain-containing protein; Belongs to the DOCK family. (189 aa)

Predicted Functional Partners:

UBIM

0.998

UBIM-2

0.998

A0A060XGD5

0.995

A0A060WTV0

0.994

A0A060XSL9

0.994

A0A060YCL2

0.994

A0A060VW29

0.993

A0A060Y577

0.993

A0A060YJN0

0.993

A0A060YLW6

0.990

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A060VW29	A0A060WTV0	A0A060VW29	A0A060WTV0	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
A0A060VW29	A0A060XGD5	A0A060VW29	A0A060XGD5	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
A0A060VW29	A0A060XSL9	A0A060VW29	A0A060XSL9	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
A0A060VW29	A0A060Y577	A0A060VW29	A0A060Y577	Ribosomal_S10 domain-containing protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.999
A0A060VW29	A0A060YCL2	A0A060VW29	A0A060YCL2	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
A0A060VW29	A0A060YJN0	A0A060VW29	A0A060YJN0	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
A0A060VW29	A0A060YLW6	A0A060VW29	A0A060YLW6	Ribosomal_S10 domain-containing protein.	Ribosomal_L18A domain-containing protein.	0.999
A0A060VW29	A0A060Z7Q0	A0A060VW29	A0A060Z7Q0	Ribosomal_S10 domain-containing protein.	DHR-2 domain-containing protein; Belongs to the DOCK family.	0.993
A0A060VW29	UBIM	A0A060VW29	C1BFG2	Ribosomal_S10 domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
A0A060VW29	UBIM-2	A0A060VW29	C1BHI8	Ribosomal_S10 domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
A0A060WTV0	A0A060VW29	A0A060WTV0	A0A060VW29	Uncharacterized protein.	Ribosomal_S10 domain-containing protein.	0.999
A0A060WTV0	A0A060XGD5	A0A060WTV0	A0A060XGD5	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A060WTV0	A0A060XSL9	A0A060WTV0	A0A060XSL9	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A060WTV0	A0A060Y577	A0A060WTV0	A0A060Y577	Uncharacterized protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.999
A0A060WTV0	A0A060YCL2	A0A060WTV0	A0A060YCL2	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A060WTV0	A0A060YJN0	A0A060WTV0	A0A060YJN0	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A060WTV0	A0A060YLW6	A0A060WTV0	A0A060YLW6	Uncharacterized protein.	Ribosomal_L18A domain-containing protein.	0.999
A0A060WTV0	A0A060Z7Q0	A0A060WTV0	A0A060Z7Q0	Uncharacterized protein.	DHR-2 domain-containing protein; Belongs to the DOCK family.	0.994
A0A060WTV0	UBIM	A0A060WTV0	C1BFG2	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
A0A060WTV0	UBIM-2	A0A060WTV0	C1BHI8	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

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