A0A060ZAR1 protein (Oncorhynchus mykiss) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A060ZAR1

Ig-like domain-containing protein. (141 aa)

Predicted Functional Partners:

A0A060WPJ7

0.998

A0A060VV14

0.971

A0A060W365

0.971

A0A060WJI2

0.971

A0A060YM58

0.971

A0A060WW50

0.970

A0A060X7U4

0.970

A0A060XBW0

0.970

A0A060YR76

0.970

A0A060YT25

0.970

Your Current Organism:

Oncorhynchus mykiss

NCBI taxonomy Id: 8022
Other names: O. mykiss, Oncorhynchus nerka mykiss, Parasalmo mykiss, Salmo mykiss, rainbow trout

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A060VV14	A0A060W365	Uncharacterized protein.	Uncharacterized protein.	0.833
A0A060VV14	A0A060WJI2	Uncharacterized protein.	Uncharacterized protein.	0.832
A0A060VV14	A0A060WPJ7	Uncharacterized protein.	Ig-like domain-containing protein.	0.911
A0A060VV14	A0A060YM58	Uncharacterized protein.	Uncharacterized protein.	0.832
A0A060VV14	A0A060ZAR1	Uncharacterized protein.	Ig-like domain-containing protein.	0.971
A0A060W365	A0A060VV14	Uncharacterized protein.	Uncharacterized protein.	0.833
A0A060W365	A0A060WPJ7	Uncharacterized protein.	Ig-like domain-containing protein.	0.911
A0A060W365	A0A060YM58	Uncharacterized protein.	Uncharacterized protein.	0.834
A0A060W365	A0A060ZAR1	Uncharacterized protein.	Ig-like domain-containing protein.	0.971
A0A060WJI2	A0A060VV14	Uncharacterized protein.	Uncharacterized protein.	0.832
A0A060WJI2	A0A060WPJ7	Uncharacterized protein.	Ig-like domain-containing protein.	0.911
A0A060WJI2	A0A060YM58	Uncharacterized protein.	Uncharacterized protein.	0.836
A0A060WJI2	A0A060ZAR1	Uncharacterized protein.	Ig-like domain-containing protein.	0.971
A0A060WPJ7	A0A060VV14	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060W365	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060WJI2	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060WW50	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060X7U4	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060XBW0	Ig-like domain-containing protein.	Uncharacterized protein.	0.911
A0A060WPJ7	A0A060YM58	Ig-like domain-containing protein.	Uncharacterized protein.	0.911

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046168

glycerol-3-phosphate catabolic process

4 of 4

3.27

4.34

1.32e-08

GO:0006116

NADH oxidation

4 of 9

2.92

3.98

4.65e-08

GO:0008654

Phospholipid biosynthetic process

4 of 158

1.67

1.53

0.00041

GO:0019637

Organophosphate metabolic process

6 of 596

1.27

1.29

0.00012

GO:0005975

Carbohydrate metabolic process

6 of 916

1.08

0.92

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004367

glycerol-3-phosphate dehydrogenase [NAD+] activity

4 of 4

3.27

4.52

6.19e-09

GO:0051287

NAD binding

4 of 69

2.03

2.21

3.15e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

4 of 5

3.17

4.56

4.68e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21423

Phospholipid/glycerol acyltransferase, and Alditol phosphate metabolic process

5 of 23

2.6

4.32

5.47e-09

CL:21424

Alditol phosphate metabolic process, and Phosphatidate phosphatase activity

4 of 12

2.79

3.68

1.48e-07

CL:21425

glycerol-3-phosphate dehydrogenase complex, and Glycerol kinase

3 of 6

2.97

2.89

5.32e-06

CL:6465

Ubiquitin domain, and Heat shock chaperonin-binding

2 of 10

2.57

1.18

0.0069

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

5 of 199

1.67

2.12

6.29e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483166

Synthesis of PA

5 of 37

2.4

4.02

1.09e-08

MAP-1483206

Glycerophospholipid biosynthesis

5 of 117

1.9

2.64

1.30e-06

MAP-1483257

Phospholipid metabolism

5 of 217

1.63

1.94

1.76e-05

MAP-556833

Metabolism of lipids

5 of 533

1.24

1.07

0.0010

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

4 of 4

3.27

4.62

3.91e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 56

2.0

1.5

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07479

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

3 of 3

3.27

2.97

4.25e-06

PF01210

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

2 of 2

3.27

1.58

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011128

Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal

3 of 3

3.27

2.71

1.25e-05

IPR006168

Glycerol-3-phosphate dehydrogenase, NAD-dependent

3 of 3

3.27

2.71

1.25e-05

IPR006109

Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal

3 of 3

3.27

2.71

1.25e-05

IPR013328

6-phosphogluconate dehydrogenase, domain 2

3 of 12

2.67

2.25

7.09e-05

IPR008927

6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily

3 of 22

2.4

1.89

0.00029

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