Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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e4f1Transcription factor E4F1 isoform X1. (823 aa)    
Predicted Functional Partners:
LOC106608673
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.847
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.847
LOC106577554
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.847
mrps11
28S ribosomal protein S11, mitochondrial isoform X1; Belongs to the universal ribosomal protein uS11 family.
   
  0.768
mrps31
28S ribosomal protein S31, mitochondrial.
    
  0.766
LOC100194649
60S ribosomal protein L26.
    
   0.753
rl26
Salmo salar 60S ribosomal protein L26 (rl26), mRNA.
    
   0.753
LOC106581268
28S ribosomal protein S23, mitochondrial-like.
    
  0.744
LOC106613080
28S ribosomal protein S23, mitochondrial-like isoform X1.
    
  0.744
asl
Argininosuccinate lyase.
      
 0.740
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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