Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fbxl18F-box/LRR-repeat protein 18 isoform X1. (758 aa)    
Predicted Functional Partners:
LOC106599302
Cullin-1; Belongs to the cullin family.
    
 0.971
LOC106569218
Cullin-1-like; Belongs to the cullin family.
    
 0.971
CUL1
Cullin-1-like; Belongs to the cullin family.
    
 0.971
SKP1
S-phase kinase associated protein 1.
    
 0.935
SKP1-2
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.935
fbxl16
F-box/LRR-repeat protein 16.
    
 
 0.859
rbx1
RING-box protein 1; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and arih1 collaborate in tandem to mediate ubiquitination of target proteins, arih1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein ligase complexes d [...]
    
 0.850
ENSSSAP00000071155
annotation not available
    
 0.850
rbx1-2
Salmo salar ring-box 1 (rbx1), mRNA.
    
 0.850
LOC106612448
Cullin-3-like.
    
 0.800
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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