| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSSSAP00000012619 | IMPDH1 | ENSSSAP00000012619 | ENSSSAP00000017211 | Phosphoribosylglycinamide formyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.765 |
| ENSSSAP00000012619 | LOC106575709 | ENSSSAP00000012619 | ENSSSAP00000036221 | Phosphoribosylglycinamide formyltransferase. | Bifunctional purine biosynthesis protein PURH-like. | 0.999 |
| ENSSSAP00000012619 | LOC106577801 | ENSSSAP00000012619 | ENSSSAP00000035484 | Phosphoribosylglycinamide formyltransferase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.765 |
| ENSSSAP00000012619 | LOC106600892 | ENSSSAP00000012619 | ENSSSAP00000050245 | Phosphoribosylglycinamide formyltransferase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.999 |
| ENSSSAP00000012619 | LOC106606117 | ENSSSAP00000012619 | ENSSSAP00000009370 | Phosphoribosylglycinamide formyltransferase. | GMP reductase 1-like. | 0.765 |
| ENSSSAP00000012619 | LOC106607442 | ENSSSAP00000012619 | ENSSSAP00000006371 | Phosphoribosylglycinamide formyltransferase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.999 |
| ENSSSAP00000012619 | adssl1 | ENSSSAP00000012619 | ENSSSAP00000006372 | Phosphoribosylglycinamide formyltransferase. | Adenylosuccinate synthetase isozyme 1 B; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity); Belongs to the adenylosuccinate synthetase family. | 0.974 |
| ENSSSAP00000012619 | gart | ENSSSAP00000012619 | ENSSSAP00000032188 | Phosphoribosylglycinamide formyltransferase. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.999 |
| ENSSSAP00000012619 | itpa | ENSSSAP00000012619 | ENSSSAP00000056837 | Phosphoribosylglycinamide formyltransferase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.669 |
| ENSSSAP00000012619 | pur9 | ENSSSAP00000012619 | ENSSSAP00000058729 | Phosphoribosylglycinamide formyltransferase. | Bifunctional purine biosynthesis protein PURH. | 0.999 |
| IMPDH1 | ENSSSAP00000012619 | ENSSSAP00000017211 | ENSSSAP00000012619 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Phosphoribosylglycinamide formyltransferase. | 0.765 |
| IMPDH1 | LOC106575709 | ENSSSAP00000017211 | ENSSSAP00000036221 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Bifunctional purine biosynthesis protein PURH-like. | 0.977 |
| IMPDH1 | LOC106577801 | ENSSSAP00000017211 | ENSSSAP00000035484 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.918 |
| IMPDH1 | LOC106600892 | ENSSSAP00000017211 | ENSSSAP00000050245 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.693 |
| IMPDH1 | LOC106606117 | ENSSSAP00000017211 | ENSSSAP00000009370 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | GMP reductase 1-like. | 0.918 |
| IMPDH1 | LOC106607442 | ENSSSAP00000017211 | ENSSSAP00000006371 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.693 |
| IMPDH1 | adssl1 | ENSSSAP00000017211 | ENSSSAP00000006372 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase isozyme 1 B; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity); Belongs to the adenylosuccinate synthetase family. | 0.965 |
| IMPDH1 | gart | ENSSSAP00000017211 | ENSSSAP00000032188 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.765 |
| IMPDH1 | itpa | ENSSSAP00000017211 | ENSSSAP00000056837 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.949 |
| IMPDH1 | pur9 | ENSSSAP00000017211 | ENSSSAP00000058729 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Bifunctional purine biosynthesis protein PURH. | 0.977 |