Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC106563476Poly [ADP-ribose] polymerase. (1338 aa)    
Predicted Functional Partners:
RNF146
E3 ubiquitin-protein ligase rnf146-like.
    
 0.921
rn146
E3 ubiquitin-protein ligase rnf146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
    
 0.921
gmds
GDP-mannose 4,6 dehydratase isoform X1.
    
 
 0.901
babam1
BRISC and BRCA1-A complex member 1.
    
 0.901
LOC106607940
E3 ubiquitin-protein ligase rnf146-like.
    
 0.885
LOC106571496
E3 ubiquitin-protein ligase rnf146-like.
    
 0.885
LOC106593505
Axin-1-like.
    
 0.828
ENSSSAP00000028425
Axin-1-like.
    
 0.828
LOC106601114
Axin-1-like isoform X2.
    
 0.828
ENSSSAP00000061190
Axin 1.
    
 0.828
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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