STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC106563476Poly [ADP-ribose] polymerase. (1338 aa)    
Predicted Functional Partners:
RNF146
E3 ubiquitin-protein ligase rnf146-like.
    
 0.902
rn146
E3 ubiquitin-protein ligase rnf146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
    
 0.902
LOC106607940
E3 ubiquitin-protein ligase rnf146-like.
    
 0.847
LOC106571496
E3 ubiquitin-protein ligase rnf146-like.
    
 0.847
LOC106593505
Axin-1-like.
    
 0.789
AXIN2
Axin-2-like.
    
 0.789
ENSSSAP00000017717
annotation not available
    
 0.789
LOC106606676
Axin-2-like.
    
 0.789
ENSSSAP00000028425
Axin-1-like.
    
 0.789
LOC106601114
Axin-1-like isoform X2.
    
 0.789
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.