close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC106576565Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (587 aa)    
Predicted Functional Partners:
wrn
Werner syndrome ATP-dependent helicase isoform X2.
    
 0.903
chek1
Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.
    
 0.830
atm
Non-specific serine/threonine protein kinase.
   
 0.814
pwwp2a
PWWP domain-containing protein 2A isoform X1.
   
 0.814
ENSSSAP00000105257
Serine-protein kinase ATM-like.
   
 0.814
LOC100194654
Salmo salar ribosomal protein S27-3 (LOC100194654), mRNA.
    
 0.809
LOC106577118
ubiquitin-40S ribosomal protein S27a.
    
 0.809
LOC106560594
WW domain-containing transcription regulator protein 1-like isoform X2.
    
 0.807
LOC106613407
Transcriptional coactivator YAP1-like.
    
 0.807
LOC106581582
Transcriptional coactivator YAP1-like.
    
 0.807
Your Current Organism:
Salmo salar
NCBI taxonomy Id: 8030
Other names: Atlantic salmon, S. salar
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.