ENSGMOP00000002334 protein (Gadus morhua) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

ENSGMOP00000002334

annotation not available (676 aa)

Predicted Functional Partners:

ENSGMOP00000000210

0.688

ENSGMOP00000003221

0.688

ENSGMOP00000018356

0.684

ENSGMOP00000008170

0.540

ENSGMOP00000009531

0.540

ENSGMOP00000013528

0.540

ENSGMOP00000014712

0.540

ENSGMOP00000018254

0.540

ENSGMOP00000007060

0.443

ENSGMOP00000006770

0.427

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSGMOP00000000210	ENSGMOP00000002334	Nuclear receptor binding protein 1.	annotation not available	0.688
ENSGMOP00000000210	ENSGMOP00000006770	Nuclear receptor binding protein 1.	Nuclear receptor binding protein 2b.	0.539
ENSGMOP00000002334	ENSGMOP00000000210	annotation not available	Nuclear receptor binding protein 1.	0.688
ENSGMOP00000002334	ENSGMOP00000003221	annotation not available	annotation not available	0.688
ENSGMOP00000002334	ENSGMOP00000006770	annotation not available	Nuclear receptor binding protein 2b.	0.427
ENSGMOP00000002334	ENSGMOP00000007060	annotation not available	annotation not available	0.443
ENSGMOP00000002334	ENSGMOP00000008170	annotation not available	Kinase suppressor of ras 2.	0.540
ENSGMOP00000002334	ENSGMOP00000009531	annotation not available	Kinase suppressor of ras 1a.	0.540
ENSGMOP00000002334	ENSGMOP00000013528	annotation not available	A-Raf proto-oncogene, serine/threonine kinase.	0.540
ENSGMOP00000002334	ENSGMOP00000014712	annotation not available	B-Raf proto-oncogene, serine/threonine kinase.	0.540
ENSGMOP00000002334	ENSGMOP00000018254	annotation not available	Raf-1 proto-oncogene, serine/threonine kinase a.	0.540
ENSGMOP00000002334	ENSGMOP00000018356	annotation not available	Serum/glucocorticoid regulated kinase family member 3.	0.684
ENSGMOP00000003221	ENSGMOP00000002334	annotation not available	annotation not available	0.688
ENSGMOP00000003221	ENSGMOP00000006770	annotation not available	Nuclear receptor binding protein 2b.	0.541
ENSGMOP00000006770	ENSGMOP00000000210	Nuclear receptor binding protein 2b.	Nuclear receptor binding protein 1.	0.539
ENSGMOP00000006770	ENSGMOP00000002334	Nuclear receptor binding protein 2b.	annotation not available	0.427
ENSGMOP00000006770	ENSGMOP00000003221	Nuclear receptor binding protein 2b.	annotation not available	0.541
ENSGMOP00000007060	ENSGMOP00000002334	annotation not available	annotation not available	0.443
ENSGMOP00000007060	ENSGMOP00000008170	annotation not available	Kinase suppressor of ras 2.	0.503
ENSGMOP00000007060	ENSGMOP00000009531	annotation not available	Kinase suppressor of ras 1a.	0.503

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006893

Golgi to plasma membrane transport

8 of 31

2.63

8.09

5.02e-17

GO:0006887

Exocytosis

11 of 152

2.08

6.95

1.53e-19

GO:0090522

Vesicle tethering involved in exocytosis

3 of 3

3.22

3.13

2.11e-06

GO:0140029

Exocytic process

4 of 47

2.15

2.52

9.07e-06

GO:2000535

Regulation of entry of bacterium into host cell

2 of 5

2.82

1.46

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031267

Small GTPase binding

6 of 213

1.67

2.23

2.99e-06

GO:0047485

Protein N-terminus binding

3 of 44

2.06

1.38

0.0022

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

3 of 51

1.99

1.34

0.0025

GO:0035091

Phosphatidylinositol binding

4 of 213

1.5

1.11

0.0030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

11 of 17

3.03

14.82

1.34e-29

GO:0090543

Flemming body

3 of 15

2.52

2.4

3.23e-05

GO:0030496

Midbody

4 of 107

1.79

1.9

7.18e-05

GO:0032584

Growth cone membrane

2 of 6

2.74

1.58

0.0013

GO:0030426

Growth cone

3 of 62

1.91

1.47

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20165

Exocyst

11 of 11

3.22

15.74

1.37e-30

CL:20168

Exocyst

6 of 6

3.22

7.89

2.82e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05132

Salmonella infection

4 of 262

1.41

1.09

0.0025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-264876

Insulin processing

11 of 27

2.83

13.33

1.00e-27

MAP-5620916

VxPx cargo-targeting to cilium

11 of 36

2.71

12.49

7.25e-27

MAP-5620920

Cargo trafficking to the periciliary membrane

11 of 61

2.48

10.64

8.39e-25

MAP-2980736

Peptide hormone metabolism

11 of 87

2.32

9.34

2.33e-23

MAP-5617833

Cilium Assembly

11 of 248

1.87

5.58

1.18e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000145

Exocyst

7 of 16

2.86

7.87

8.68e-16

GOCC:0071944

Cell periphery

9 of 2215

0.83

0.76

9.08e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0268

Exocytosis

4 of 6

3.05

4.53

4.79e-09

KW-0813

Transport

4 of 641

1.02

0.53

0.0446

KW-0175

Coiled coil

8 of 3376

0.6

0.39

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09763

Exocyst complex component Sec3

2 of 2

3.22

1.33

0.0041

PF04091

Exocyst complex subunit Sec15-like

2 of 2

3.22

1.33

0.0041

PF06046

Exocyst complex component Sec6

2 of 6

2.74

1.21

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046361

Exocyst complex subunit Sec15, C-terminal

2 of 2

3.22

1.05

0.0130

IPR042045

Exocyst complex component EXOC6/Sec15, C-terminal, domain 1

2 of 2

3.22

1.05

0.0130

IPR042044

EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2

2 of 3

3.05

1.05

0.0130

IPR019160

Exocyst complex component Sec3, C-terminal

2 of 2

3.22

1.05

0.0130

IPR007225

Exocyst complex component EXOC6/Sec15

2 of 2

3.22

1.05

0.0130

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01313

Exocyst complex component SEC3 N-terminal PIP2 binding PH

2 of 4

2.92

1.34

0.0037

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