STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (716 aa)    
Predicted Functional Partners:
ENSGMOP00000016441
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.952
ENSGMOP00000001378
Nedd8 activating enzyme E1 subunit 1.
    
 0.933
NCSTN
Nicastrin.
    
 0.919
ENSGMOP00000008894
Insulin-degrading enzyme.
    
 
 0.898
ENSGMOP00000010806
annotation not available
   
 
 0.880
ENSGMOP00000013219
Amyloid beta (A4) precursor protein-binding, family B, member 3.
    
 0.877
ENSGMOP00000015998
Pitrilysin metallopeptidase 1.
    
 
 0.876
ENSGMOP00000014776
Apolipoprotein Eb.
    
 0.853
ENSGMOP00000007681
Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65).
    
 0.846
ENSGMOP00000010405
annotation not available
    
 0.846
Your Current Organism:
Gadus morhua
NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.