ENSGMOP00000004946 protein (Gadus morhua) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSGMOP00000004946

Nuclear receptor coactivator 4. (515 aa)

Predicted Functional Partners:

ENSGMOP00000004335

0.943

ENSGMOP00000010954

0.943

ENSGMOP00000003541

0.927

ENSGMOP00000005764

0.922

LOC115531394

0.920

ENSGMOP00000020057

0.920

LOC115550866

0.900

LOC115558225

0.900

ENSGMOP00000001037

0.623

ENSGMOP00000004003

0.623

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGMOP00000001037	ENSGMOP00000004946	ENSGMOP00000001037	ENSGMOP00000004946	annotation not available	Nuclear receptor coactivator 4.	0.623
ENSGMOP00000001037	ENSGMOP00000020057	ENSGMOP00000001037	ENSGMOP00000020057	annotation not available	Coiled-coil domain containing 6a.	0.623
ENSGMOP00000003541	ENSGMOP00000004946	ENSGMOP00000003541	ENSGMOP00000004946	Ferritin, heavy polypeptide-like 31.	Nuclear receptor coactivator 4.	0.927
ENSGMOP00000003541	LOC115531394	ENSGMOP00000003541	ENSGMOP00000005905	Ferritin, heavy polypeptide-like 31.	Ferritin, heavy subunit-like.	0.845
ENSGMOP00000003541	LOC115550866	ENSGMOP00000003541	ENSGMOP00000019429	Ferritin, heavy polypeptide-like 31.	Ferritin, heavy subunit-like.	0.841
ENSGMOP00000003541	LOC115558225	ENSGMOP00000003541	ENSGMOP00000020041	Ferritin, heavy polypeptide-like 31.	Ferritin, heavy subunit.	0.841
ENSGMOP00000004003	ENSGMOP00000004946	ENSGMOP00000004003	ENSGMOP00000004946	Fibroblast growth factor receptor 3.	Nuclear receptor coactivator 4.	0.623
ENSGMOP00000004003	ENSGMOP00000020057	ENSGMOP00000004003	ENSGMOP00000020057	Fibroblast growth factor receptor 3.	Coiled-coil domain containing 6a.	0.623
ENSGMOP00000004335	ENSGMOP00000004946	ENSGMOP00000004335	ENSGMOP00000004946	annotation not available	Nuclear receptor coactivator 4.	0.943
ENSGMOP00000004335	ENSGMOP00000010954	ENSGMOP00000004335	ENSGMOP00000010954	annotation not available	Androgen receptor.	0.845
ENSGMOP00000004946	ENSGMOP00000001037	ENSGMOP00000004946	ENSGMOP00000001037	Nuclear receptor coactivator 4.	annotation not available	0.623
ENSGMOP00000004946	ENSGMOP00000003541	ENSGMOP00000004946	ENSGMOP00000003541	Nuclear receptor coactivator 4.	Ferritin, heavy polypeptide-like 31.	0.927
ENSGMOP00000004946	ENSGMOP00000004003	ENSGMOP00000004946	ENSGMOP00000004003	Nuclear receptor coactivator 4.	Fibroblast growth factor receptor 3.	0.623
ENSGMOP00000004946	ENSGMOP00000004335	ENSGMOP00000004946	ENSGMOP00000004335	Nuclear receptor coactivator 4.	annotation not available	0.943
ENSGMOP00000004946	ENSGMOP00000005764	ENSGMOP00000004946	ENSGMOP00000005764	Nuclear receptor coactivator 4.	Ret proto-oncogene receptor tyrosine kinase.	0.922
ENSGMOP00000004946	ENSGMOP00000010954	ENSGMOP00000004946	ENSGMOP00000010954	Nuclear receptor coactivator 4.	Androgen receptor.	0.943
ENSGMOP00000004946	ENSGMOP00000020057	ENSGMOP00000004946	ENSGMOP00000020057	Nuclear receptor coactivator 4.	Coiled-coil domain containing 6a.	0.920
ENSGMOP00000004946	LOC115531394	ENSGMOP00000004946	ENSGMOP00000005905	Nuclear receptor coactivator 4.	Ferritin, heavy subunit-like.	0.920
ENSGMOP00000004946	LOC115550866	ENSGMOP00000004946	ENSGMOP00000019429	Nuclear receptor coactivator 4.	Ferritin, heavy subunit-like.	0.900
ENSGMOP00000004946	LOC115558225	ENSGMOP00000004946	ENSGMOP00000020041	Nuclear receptor coactivator 4.	Ferritin, heavy subunit.	0.900

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About