ENSGMOP00000006152 protein (Gadus morhua) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ENSGMOP00000006152

ADP-ribosylhydrolase like 1. (353 aa)

Predicted Functional Partners:

ENSGMOP00000004304

0.838

ube2m

0.838

ENSGMOP00000004325

0.805

ENSGMOP00000002178

0.803

ENSGMOP00000007930

0.803

ENSGMOP00000006085

0.748

ENSGMOP00000006374

0.748

CUL3

0.748

ENSGMOP00000018480

0.748

ENSGMOP00000019476

0.748

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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... protein annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	ENSGMOP00000002178	ENSGMOP00000006604	ENSGMOP00000002178	Cullin-3-like.	Ring-box 1, E3 ubiquitin protein ligase.	0.983
CUL3	ENSGMOP00000004304	ENSGMOP00000006604	ENSGMOP00000004304	Cullin-3-like.	Ubiquitin-conjugating enzyme E2F (putative).	0.883
CUL3	ENSGMOP00000004325	ENSGMOP00000006604	ENSGMOP00000004325	Cullin-3-like.	NEDD8 ubiquitin like modifier, like.	0.962
CUL3	ENSGMOP00000006152	ENSGMOP00000006604	ENSGMOP00000006152	Cullin-3-like.	ADP-ribosylhydrolase like 1.	0.748
CUL3	ENSGMOP00000006374	ENSGMOP00000006604	ENSGMOP00000006374	Cullin-3-like.	annotation not available	0.645
CUL3	ENSGMOP00000007930	ENSGMOP00000006604	ENSGMOP00000007930	Cullin-3-like.	Ring finger protein 7.	0.923
CUL3	ENSGMOP00000019476	ENSGMOP00000006604	ENSGMOP00000019476	Cullin-3-like.	Cullin 1a.	0.645
CUL3	ube2m	ENSGMOP00000006604	ENSGMOP00000012384	Cullin-3-like.	Ubiquitin conjugating enzyme E2 M.	0.883
ENSGMOP00000002178	CUL3	ENSGMOP00000002178	ENSGMOP00000006604	Ring-box 1, E3 ubiquitin protein ligase.	Cullin-3-like.	0.983
ENSGMOP00000002178	ENSGMOP00000004304	ENSGMOP00000002178	ENSGMOP00000004304	Ring-box 1, E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2F (putative).	0.976
ENSGMOP00000002178	ENSGMOP00000004325	ENSGMOP00000002178	ENSGMOP00000004325	Ring-box 1, E3 ubiquitin protein ligase.	NEDD8 ubiquitin like modifier, like.	0.994
ENSGMOP00000002178	ENSGMOP00000006085	ENSGMOP00000002178	ENSGMOP00000006085	Ring-box 1, E3 ubiquitin protein ligase.	CDK2 associated cullin domain 1.	0.888
ENSGMOP00000002178	ENSGMOP00000006152	ENSGMOP00000002178	ENSGMOP00000006152	Ring-box 1, E3 ubiquitin protein ligase.	ADP-ribosylhydrolase like 1.	0.803
ENSGMOP00000002178	ENSGMOP00000006374	ENSGMOP00000002178	ENSGMOP00000006374	Ring-box 1, E3 ubiquitin protein ligase.	annotation not available	0.990
ENSGMOP00000002178	ENSGMOP00000007930	ENSGMOP00000002178	ENSGMOP00000007930	Ring-box 1, E3 ubiquitin protein ligase.	Ring finger protein 7.	0.798
ENSGMOP00000002178	ENSGMOP00000018480	ENSGMOP00000002178	ENSGMOP00000018480	Ring-box 1, E3 ubiquitin protein ligase.	Cullin 3b.	0.983
ENSGMOP00000002178	ENSGMOP00000019476	ENSGMOP00000002178	ENSGMOP00000019476	Ring-box 1, E3 ubiquitin protein ligase.	Cullin 1a.	0.990
ENSGMOP00000002178	ube2m	ENSGMOP00000002178	ENSGMOP00000012384	Ring-box 1, E3 ubiquitin protein ligase.	Ubiquitin conjugating enzyme E2 M.	0.976
ENSGMOP00000004304	CUL3	ENSGMOP00000004304	ENSGMOP00000006604	Ubiquitin-conjugating enzyme E2F (putative).	Cullin-3-like.	0.883
ENSGMOP00000004304	ENSGMOP00000002178	ENSGMOP00000004304	ENSGMOP00000002178	Ubiquitin-conjugating enzyme E2F (putative).	Ring-box 1, E3 ubiquitin protein ligase.	0.976

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.842

expected number of edges:

10

PPI enrichment p-value:

2.73e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007265

Ras protein signal transduction

8 of 149

2.14

5.2

1.03e-12

GO:0007266

Rho protein signal transduction

3 of 54

2.15

1.51

0.0013

GO:1903975

Regulation of glial cell migration

2 of 9

2.75

1.24

0.0056

GO:0032535

Regulation of cellular component size

4 of 316

1.51

1.07

0.0041

GO:0008361

Regulation of cell size

3 of 151

1.71

0.9

0.0160

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

8 of 391

1.72

3.25

6.50e-10

GO:0005525

GTP binding

8 of 603

1.53

2.52

9.87e-09

GO:0019003

GDP binding

3 of 51

2.18

1.96

0.00016

GO:0005096

GTPase activator activity

4 of 297

1.54

1.39

0.00054

GO:0035639

Purine ribonucleoside triphosphate binding

9 of 2557

0.95

1.0

5.95e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 6425

0.6

0.45

0.0043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17135

Mixed, incl. Ras GTPase-activating protein, and Small GTPase, Ras-type

6 of 18

2.93

6.55

5.18e-13

CL:17157

Activation of RAS in B cells, and c-Kit-binding domain

3 of 5

3.19

3.0

3.58e-06

CL:17138

Core histone H2A/H2B/H3/H4, and Small GTPase, Ras-type

3 of 6

3.11

3.0

3.58e-06

CL:16875

Contains two conserved F residues, and Skeletal muscle satellite cell migration

3 of 5

3.19

3.0

3.58e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04810

Regulation of actin cytoskeleton

8 of 252

1.91

4.49

1.27e-12

onl04137

Mitophagy - animal

5 of 73

2.24

4.07

3.62e-09

onl04625

C-type lectin receptor signaling pathway

5 of 131

1.99

3.29

4.58e-08

onl04010

MAPK signaling pathway

7 of 358

1.7

3.12

1.52e-09

onl04371

Apelin signaling pathway

5 of 160

1.9

3.04

9.70e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8849471

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

5 of 27

2.68

4.9

4.47e-10

MAP-9006927

Signaling by Non-Receptor Tyrosine Kinases

6 of 78

2.29

4.52

4.47e-10

MAP-8848021

Signaling by PTK6

6 of 78

2.29

4.52

4.47e-10

MAP-186763

Downstream signal transduction

4 of 39

2.42

3.29

4.29e-07

MAP-416550

Sema4D mediated inhibition of cell attachment and migration

3 of 10

2.89

3.09

2.11e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13816

0.31

0.28

0.0036

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

5 of 198

1.81

2.42

2.74e-06

KW-0547

Nucleotide-binding

6 of 1222

1.1

1.0

0.00043

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00071

Ras family

3 of 24

2.5

1.89

0.00031

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

4 of 12

2.93

3.89

6.98e-08

IPR001806

Small GTPase

6 of 117

2.12

3.63

1.70e-08

IPR005225

Small GTP-binding protein domain

4 of 141

1.86

1.63

0.00044

IPR045786

Rho GTPase-activating protein, pG1 and pG2 domain

2 of 2

3.41

1.6

0.0013

IPR039007

Rho GTPase-activating protein, pG1 domain

2 of 2

3.41

1.6

0.0013

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

5 of 26

2.69

4.92

4.26e-10

SM00441

Contains two conserved F residues

3 of 5

3.19

3.31

9.98e-07

SM00324

GTPase-activator protein for Rho-like GTPases

3 of 91

1.93

1.41

0.0016

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