ENSGMOP00000006449 protein (Gadus morhua) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

ENSGMOP00000006449

Elongator complex protein 1. (1308 aa)

Predicted Functional Partners:

ENSGMOP00000007388

0.997

elp4

0.993

ENSGMOP00000008379

0.983

ENSGMOP00000017679

0.980

ENSGMOP00000000146

0.891

ENSGMOP00000016774

0.856

ENSGMOP00000010220

0.815

kti12

0.808

ENSGMOP00000018606

0.808

ENSGMOP00000008867

0.804

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGMOP00000000146	ENSGMOP00000006449	ENSGMOP00000000146	ENSGMOP00000006449	annotation not available	Elongator complex protein 1.	0.891
ENSGMOP00000000146	ENSGMOP00000007388	ENSGMOP00000000146	ENSGMOP00000007388	annotation not available	Elongator acetyltransferase complex subunit 3.	0.913
ENSGMOP00000000146	ENSGMOP00000008379	ENSGMOP00000000146	ENSGMOP00000008379	annotation not available	Elongator acetyltransferase complex subunit 5.	0.593
ENSGMOP00000000146	ENSGMOP00000018606	ENSGMOP00000000146	ENSGMOP00000018606	annotation not available	Neuromedin Bb.	0.487
ENSGMOP00000000146	elp4	ENSGMOP00000000146	ENSGMOP00000013171	annotation not available	Elongator acetyltransferase complex subunit 4.	0.593
ENSGMOP00000000146	kti12	ENSGMOP00000000146	ENSGMOP00000007109	annotation not available	KTI12 chromatin associated homolog.	0.487
ENSGMOP00000006449	ENSGMOP00000000146	ENSGMOP00000006449	ENSGMOP00000000146	Elongator complex protein 1.	annotation not available	0.891
ENSGMOP00000006449	ENSGMOP00000007388	ENSGMOP00000006449	ENSGMOP00000007388	Elongator complex protein 1.	Elongator acetyltransferase complex subunit 3.	0.997
ENSGMOP00000006449	ENSGMOP00000008379	ENSGMOP00000006449	ENSGMOP00000008379	Elongator complex protein 1.	Elongator acetyltransferase complex subunit 5.	0.983
ENSGMOP00000006449	ENSGMOP00000008867	ENSGMOP00000006449	ENSGMOP00000008867	Elongator complex protein 1.	WD repeat domain 75.	0.804
ENSGMOP00000006449	ENSGMOP00000010220	ENSGMOP00000006449	ENSGMOP00000010220	Elongator complex protein 1.	annotation not available	0.815
ENSGMOP00000006449	ENSGMOP00000016774	ENSGMOP00000006449	ENSGMOP00000016774	Elongator complex protein 1.	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae).	0.856
ENSGMOP00000006449	ENSGMOP00000017679	ENSGMOP00000006449	ENSGMOP00000017679	Elongator complex protein 1.	Elongator acetyltransferase complex subunit 2.	0.980
ENSGMOP00000006449	ENSGMOP00000018606	ENSGMOP00000006449	ENSGMOP00000018606	Elongator complex protein 1.	Neuromedin Bb.	0.808
ENSGMOP00000006449	elp4	ENSGMOP00000006449	ENSGMOP00000013171	Elongator complex protein 1.	Elongator acetyltransferase complex subunit 4.	0.993
ENSGMOP00000006449	kti12	ENSGMOP00000006449	ENSGMOP00000007109	Elongator complex protein 1.	KTI12 chromatin associated homolog.	0.808
ENSGMOP00000007388	ENSGMOP00000000146	ENSGMOP00000007388	ENSGMOP00000000146	Elongator acetyltransferase complex subunit 3.	annotation not available	0.913
ENSGMOP00000007388	ENSGMOP00000006449	ENSGMOP00000007388	ENSGMOP00000006449	Elongator acetyltransferase complex subunit 3.	Elongator complex protein 1.	0.997
ENSGMOP00000007388	ENSGMOP00000008379	ENSGMOP00000007388	ENSGMOP00000008379	Elongator acetyltransferase complex subunit 3.	Elongator acetyltransferase complex subunit 5.	0.983
ENSGMOP00000007388	ENSGMOP00000008867	ENSGMOP00000007388	ENSGMOP00000008867	Elongator acetyltransferase complex subunit 3.	WD repeat domain 75.	0.478

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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