ENSGMOP00000009810 protein (Gadus morhua) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSGMOP00000009810

annotation not available (417 aa)

Predicted Functional Partners:

ENSGMOP00000002591

0.722

ENSGMOP00000001984

0.686

ENSGMOP00000016337

0.652

ENSGMOP00000014392

0.651

ENSGMOP00000018190

0.620

ENSGMOP00000020526

0.620

ENSGMOP00000011392

0.619

ENSGMOP00000011842

0.619

ENSGMOP00000016284

0.619

ENSGMOP00000017059

0.619

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSGMOP00000001984	ENSGMOP00000009810	Peripherin.	annotation not available	0.686
ENSGMOP00000002591	ENSGMOP00000009810	annotation not available	annotation not available	0.722
ENSGMOP00000009810	ENSGMOP00000001984	annotation not available	Peripherin.	0.686
ENSGMOP00000009810	ENSGMOP00000002591	annotation not available	annotation not available	0.722
ENSGMOP00000009810	ENSGMOP00000011392	annotation not available	annotation not available	0.619
ENSGMOP00000009810	ENSGMOP00000011842	annotation not available	Calsequestrin 2.	0.619
ENSGMOP00000009810	ENSGMOP00000014392	annotation not available	annotation not available	0.651
ENSGMOP00000009810	ENSGMOP00000016284	annotation not available	Calsequestrin 1a.	0.619
ENSGMOP00000009810	ENSGMOP00000016337	annotation not available	Superoxide dismutase 1, soluble.	0.652
ENSGMOP00000009810	ENSGMOP00000017059	annotation not available	Calsequestrin 1b.	0.619
ENSGMOP00000009810	ENSGMOP00000018190	annotation not available	annotation not available	0.620
ENSGMOP00000009810	ENSGMOP00000020526	annotation not available	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	0.620
ENSGMOP00000011392	ENSGMOP00000009810	annotation not available	annotation not available	0.619
ENSGMOP00000011392	ENSGMOP00000011842	annotation not available	Calsequestrin 2.	0.844
ENSGMOP00000011392	ENSGMOP00000014392	annotation not available	annotation not available	0.901
ENSGMOP00000011392	ENSGMOP00000016284	annotation not available	Calsequestrin 1a.	0.844
ENSGMOP00000011392	ENSGMOP00000017059	annotation not available	Calsequestrin 1b.	0.777
ENSGMOP00000011842	ENSGMOP00000009810	Calsequestrin 2.	annotation not available	0.619
ENSGMOP00000011842	ENSGMOP00000011392	Calsequestrin 2.	annotation not available	0.844
ENSGMOP00000011842	ENSGMOP00000014392	Calsequestrin 2.	annotation not available	0.901

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.331

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006893

Golgi to plasma membrane transport

8 of 31

2.63

8.09

5.02e-17

GO:0006887

Exocytosis

11 of 152

2.08

6.95

1.53e-19

GO:0090522

Vesicle tethering involved in exocytosis

3 of 3

3.22

3.13

2.11e-06

GO:0140029

Exocytic process

4 of 47

2.15

2.52

9.07e-06

GO:2000535

Regulation of entry of bacterium into host cell

2 of 5

2.82

1.46

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031267

Small GTPase binding

6 of 213

1.67

2.23

2.99e-06

GO:0047485

Protein N-terminus binding

3 of 44

2.06

1.38

0.0022

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

3 of 51

1.99

1.34

0.0025

GO:0035091

Phosphatidylinositol binding

4 of 213

1.5

1.11

0.0030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

11 of 17

3.03

14.82

1.34e-29

GO:0090543

Flemming body

3 of 15

2.52

2.4

3.23e-05

GO:0030496

Midbody

4 of 107

1.79

1.9

7.18e-05

GO:0032584

Growth cone membrane

2 of 6

2.74

1.58

0.0013

GO:0030426

Growth cone

3 of 62

1.91

1.47

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20165

Exocyst

11 of 11

3.22

15.74

1.37e-30

CL:20168

Exocyst

6 of 6

3.22

7.89

2.82e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05132

Salmonella infection

4 of 262

1.41

1.09

0.0025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-264876

Insulin processing

11 of 27

2.83

13.33

1.00e-27

MAP-5620916

VxPx cargo-targeting to cilium

11 of 36

2.71

12.49

7.25e-27

MAP-5620920

Cargo trafficking to the periciliary membrane

11 of 61

2.48

10.64

8.39e-25

MAP-2980736

Peptide hormone metabolism

11 of 87

2.32

9.34

2.33e-23

MAP-5617833

Cilium Assembly

11 of 248

1.87

5.58

1.18e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000145

Exocyst

7 of 16

2.86

7.87

8.68e-16

GOCC:0071944

Cell periphery

9 of 2215

0.83

0.76

9.08e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0268

Exocytosis

4 of 6

3.05

4.53

4.79e-09

KW-0813

Transport

4 of 641

1.02

0.53

0.0446

KW-0175

Coiled coil

8 of 3376

0.6

0.39

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09763

Exocyst complex component Sec3

2 of 2

3.22

1.33

0.0041

PF04091

Exocyst complex subunit Sec15-like

2 of 2

3.22

1.33

0.0041

PF06046

Exocyst complex component Sec6

2 of 6

2.74

1.21

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046361

Exocyst complex subunit Sec15, C-terminal

2 of 2

3.22

1.05

0.0130

IPR042045

Exocyst complex component EXOC6/Sec15, C-terminal, domain 1

2 of 2

3.22

1.05

0.0130

IPR042044

EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2

2 of 3

3.05

1.05

0.0130

IPR019160

Exocyst complex component Sec3, C-terminal

2 of 2

3.22

1.05

0.0130

IPR007225

Exocyst complex component EXOC6/Sec15

2 of 2

3.22

1.05

0.0130

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01313

Exocyst complex component SEC3 N-terminal PIP2 binding PH

2 of 4

2.92

1.34

0.0037

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