ENSGMOP00000012486 protein (Gadus morhua) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSGMOP00000012486

Deoxyribonuclease 1 like 4, tandem duplicate 1. (274 aa)

Predicted Functional Partners:

ENSGMOP00000015833

0.959

ENSGMOP00000018256

0.959

ENSGMOP00000006581

0.918

ENSGMOP00000003084

0.906

ENSGMOP00000009196

0.905

ENSGMOP00000004007

0.886

ENSGMOP00000009024

0.861

ENSGMOP00000012153

0.861

TRAF2

0.861

ENSGMOP00000015237

0.861

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGMOP00000003084	ENSGMOP00000006581	ENSGMOP00000003084	ENSGMOP00000006581	Tnfrsf1a-associated via death domain.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.934
ENSGMOP00000003084	ENSGMOP00000009024	ENSGMOP00000003084	ENSGMOP00000009024	Tnfrsf1a-associated via death domain.	annotation not available	0.979
ENSGMOP00000003084	ENSGMOP00000012153	ENSGMOP00000003084	ENSGMOP00000012153	Tnfrsf1a-associated via death domain.	Tnf receptor-associated factor 2b.	0.984
ENSGMOP00000003084	ENSGMOP00000012486	ENSGMOP00000003084	ENSGMOP00000012486	Tnfrsf1a-associated via death domain.	Deoxyribonuclease 1 like 4, tandem duplicate 1.	0.906
ENSGMOP00000003084	ENSGMOP00000015237	ENSGMOP00000003084	ENSGMOP00000015237	Tnfrsf1a-associated via death domain.	TNF receptor-associated factor 3.	0.969
ENSGMOP00000003084	ENSGMOP00000015833	ENSGMOP00000003084	ENSGMOP00000015833	Tnfrsf1a-associated via death domain.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.795
ENSGMOP00000003084	ENSGMOP00000018256	ENSGMOP00000003084	ENSGMOP00000018256	Tnfrsf1a-associated via death domain.	TANK-binding kinase 1.	0.795
ENSGMOP00000003084	TRAF2	ENSGMOP00000003084	ENSGMOP00000012548	Tnfrsf1a-associated via death domain.	TNF receptor associated factor 2.	0.979
ENSGMOP00000004007	ENSGMOP00000006581	ENSGMOP00000004007	ENSGMOP00000006581	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.870
ENSGMOP00000004007	ENSGMOP00000009196	ENSGMOP00000004007	ENSGMOP00000009196	5-azacytidine induced 2.	TBK1 binding protein 1.	0.894
ENSGMOP00000004007	ENSGMOP00000012486	ENSGMOP00000004007	ENSGMOP00000012486	5-azacytidine induced 2.	Deoxyribonuclease 1 like 4, tandem duplicate 1.	0.886
ENSGMOP00000004007	ENSGMOP00000015833	ENSGMOP00000004007	ENSGMOP00000015833	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.879
ENSGMOP00000004007	ENSGMOP00000018256	ENSGMOP00000004007	ENSGMOP00000018256	5-azacytidine induced 2.	TANK-binding kinase 1.	0.879
ENSGMOP00000006581	ENSGMOP00000003084	ENSGMOP00000006581	ENSGMOP00000003084	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Tnfrsf1a-associated via death domain.	0.934
ENSGMOP00000006581	ENSGMOP00000004007	ENSGMOP00000006581	ENSGMOP00000004007	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	5-azacytidine induced 2.	0.870
ENSGMOP00000006581	ENSGMOP00000009024	ENSGMOP00000006581	ENSGMOP00000009024	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	annotation not available	0.862
ENSGMOP00000006581	ENSGMOP00000009196	ENSGMOP00000006581	ENSGMOP00000009196	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TBK1 binding protein 1.	0.855
ENSGMOP00000006581	ENSGMOP00000012153	ENSGMOP00000006581	ENSGMOP00000012153	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Tnf receptor-associated factor 2b.	0.865
ENSGMOP00000006581	ENSGMOP00000012486	ENSGMOP00000006581	ENSGMOP00000012486	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Deoxyribonuclease 1 like 4, tandem duplicate 1.	0.918
ENSGMOP00000006581	ENSGMOP00000015237	ENSGMOP00000006581	ENSGMOP00000015237	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor 3.	0.914

page 1 of 5

Network Stats

number of nodes:

9

number of edges:

15

average node degree:

3.33

avg. local clustering coefficient:

0.917

expected number of edges:

16

PPI enrichment p-value:

0.675

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006479

Protein methylation

6 of 57

1.9

2.91

2.29e-07

GO:0016571

Histone methylation

4 of 25

2.08

2.31

2.22e-05

GO:0006325

Chromatin organization

7 of 177

1.48

2.04

8.15e-07

GO:0051568

Histone H3-K4 methylation

3 of 11

2.31

1.91

0.00024

GO:0016570

Histone modification

5 of 88

1.63

1.88

2.97e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

3 of 9

2.4

1.75

0.00055

GO:0046982

Protein heterodimerization activity

3 of 29

1.89

1.13

0.0061

GO:0042800

Histone methyltransferase activity (H3-K4 specific)

2 of 5

2.48

0.98

0.0162

GO:0005515

Protein binding

6 of 689

0.82

0.48

0.0311

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

4 of 9

2.53

3.22

7.64e-07

GO:0048188

Set1C/COMPASS complex

3 of 8

2.45

2.34

3.90e-05

GO:0000786

Nucleosome

3 of 11

2.31

2.18

6.80e-05

GO:0005694

Chromosome

8 of 326

1.27

1.64

7.64e-07

GO:0070210

Rpd3L-Expanded complex

2 of 3

2.7

1.62

0.0011

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34202282

(2021) Using Genealogical Concordance and Coalescent-Based Species Delimitation to Assess Species Boundaries in the Diaporthe eres Complex.

2 of 2

2.88

1.82

0.00049

PMID:25264384

(2014) Species limits in Diaporthe: molecular re-assessment of D. citri, D. cytosporella, D. foeniculina and D. rudis.

2 of 2

2.88

1.82

0.00049

PMID:34456375

(2020) Mating genes in Calonectria and evidence for a heterothallic ancestral state.

2 of 3

2.7

1.81

0.00049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2696

Histone methyltransferase complex, and Structural constituent of chromatin

8 of 25

2.38

6.92

1.24e-15

CL:2689

PKMTs methylate histone lysines, and Structural constituent of chromatin

9 of 37

2.26

6.86

1.78e-16

CL:2475

Mixed, incl. Histone modification, and Chromatin remodeling

10 of 171

1.65

3.75

3.88e-14

CL:2726

Set1C/COMPASS complex, and Histone H3

4 of 10

2.48

3.49

1.97e-07

CL:2699

Mixed, incl. Nucleosome core, and Regulation of PTEN gene transcription

4 of 13

2.37

3.26

4.33e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00310

Lysine degradation

3 of 82

1.44

0.76

0.0240

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 29

2.11

3.1

3.48e-07

MAP-4839726

Chromatin organization

6 of 81

1.75

2.62

3.48e-07

MAP-3247509

Chromatin modifying enzymes

6 of 81

1.75

2.62

3.48e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.28

1.66

0.00072

GOCC:0035097

Histone methyltransferase complex

3 of 14

2.21

1.65

0.00072

GOCC:0070210

Rpd3L-Expanded complex

2 of 5

2.48

1.31

0.0039

GOCC:0000785

Chromatin

5 of 145

1.42

1.26

0.00072

GOCC:0048188

Set1C/COMPASS complex

2 of 7

2.33

1.2

0.0060

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 10

2.36

2.07

0.00012

KW-0544

Nucleosome core

2 of 5

2.48

1.4

0.0026

KW-0539

Nucleus

6 of 309

1.17

1.16

0.00013

KW-0853

WD repeat

3 of 99

1.36

0.79

0.0164

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007125

Histone H2A/H2B/H3

3 of 6

2.58

1.85

0.00038

IPR000164

Histone H3/CENP-A

2 of 2

2.88

1.15

0.0083

IPR009072

Histone-fold

3 of 25

1.96

1.11

0.0073

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

2 of 3

2.7

1.27

0.0049

SM00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

2 of 14

2.03

0.82

0.0292

SM00320

WD40 repeats

3 of 113

1.3

0.63

0.0415

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