ENSGMOP00000013461 protein (Gadus morhua) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSGMOP00000013461

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A. (538 aa)

Predicted Functional Partners:

ENSGMOP00000019988

0.893

ENSGMOP00000003352

0.871

ENSGMOP00000009183

0.858

ENSGMOP00000011556

0.857

ENSGMOP00000011122

0.847

ENSGMOP00000018558

0.844

ENSGMOP00000003602

0.839

ENSGMOP00000006496

0.795

ENSGMOP00000004891

0.792

ENSGMOP00000008051

0.792

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSGMOP00000003352	ENSGMOP00000003602	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	annotation not available	0.680
ENSGMOP00000003352	ENSGMOP00000006496	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	annotation not available	0.679
ENSGMOP00000003352	ENSGMOP00000009183	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Si:ch73-91k6.2.	0.904
ENSGMOP00000003352	ENSGMOP00000011122	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Mgat4 family member C.	0.680
ENSGMOP00000003352	ENSGMOP00000011556	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.	0.904
ENSGMOP00000003352	ENSGMOP00000013461	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A.	0.871
ENSGMOP00000003352	ENSGMOP00000018558	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B.	0.880
ENSGMOP00000003352	ENSGMOP00000019988	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase.	0.407
ENSGMOP00000003602	ENSGMOP00000003352	annotation not available	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	0.680
ENSGMOP00000003602	ENSGMOP00000004891	annotation not available	annotation not available	0.811
ENSGMOP00000003602	ENSGMOP00000006496	annotation not available	annotation not available	0.849
ENSGMOP00000003602	ENSGMOP00000008051	annotation not available	annotation not available	0.811
ENSGMOP00000003602	ENSGMOP00000009183	annotation not available	Si:ch73-91k6.2.	0.625
ENSGMOP00000003602	ENSGMOP00000011122	annotation not available	Mgat4 family member C.	0.843
ENSGMOP00000003602	ENSGMOP00000011556	annotation not available	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.	0.625
ENSGMOP00000003602	ENSGMOP00000013461	annotation not available	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A.	0.839
ENSGMOP00000003602	ENSGMOP00000019988	annotation not available	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase.	0.894
ENSGMOP00000004891	ENSGMOP00000003602	annotation not available	annotation not available	0.811
ENSGMOP00000004891	ENSGMOP00000006496	annotation not available	annotation not available	0.773
ENSGMOP00000004891	ENSGMOP00000011122	annotation not available	Mgat4 family member C.	0.815

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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