ENSGMOP00000014654 protein (Gadus morhua) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

ENSGMOP00000014654

annotation not available (305 aa)

Predicted Functional Partners:

ENSGMOP00000005393

0.699

ENSGMOP00000005408

0.699

LOC115544135

0.699

ENSGMOP00000015641

0.699

ENSGMOP00000011651

0.654

ENSGMOP00000011688

0.654

ENSGMOP00000011745

0.654

ENSGMOP00000011750

0.654

ENSGMOP00000011758

0.654

ENSGMOP00000016255

0.654

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGMOP00000005393	ENSGMOP00000005408	ENSGMOP00000005393	ENSGMOP00000005408	annotation not available	Guanine nucleotide binding protein (G protein), alpha 14a.	0.841
ENSGMOP00000005393	ENSGMOP00000011651	ENSGMOP00000005393	ENSGMOP00000011651	annotation not available	annotation not available	0.498
ENSGMOP00000005393	ENSGMOP00000011688	ENSGMOP00000005393	ENSGMOP00000011688	annotation not available	annotation not available	0.498
ENSGMOP00000005393	ENSGMOP00000011745	ENSGMOP00000005393	ENSGMOP00000011745	annotation not available	annotation not available	0.498
ENSGMOP00000005393	ENSGMOP00000011750	ENSGMOP00000005393	ENSGMOP00000011750	annotation not available	annotation not available	0.498
ENSGMOP00000005393	ENSGMOP00000011758	ENSGMOP00000005393	ENSGMOP00000011758	annotation not available	annotation not available	0.498
ENSGMOP00000005393	ENSGMOP00000014654	ENSGMOP00000005393	ENSGMOP00000014654	annotation not available	annotation not available	0.699
ENSGMOP00000005393	ENSGMOP00000015641	ENSGMOP00000005393	ENSGMOP00000015641	annotation not available	annotation not available	0.827
ENSGMOP00000005393	ENSGMOP00000016255	ENSGMOP00000005393	ENSGMOP00000016255	annotation not available	annotation not available	0.498
ENSGMOP00000005393	LOC115544135	ENSGMOP00000005393	ENSGMOP00000012905	annotation not available	Guanine nucleotide-binding protein G(q) subunit alpha-like.	0.827
ENSGMOP00000005408	ENSGMOP00000005393	ENSGMOP00000005408	ENSGMOP00000005393	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.841
ENSGMOP00000005408	ENSGMOP00000011651	ENSGMOP00000005408	ENSGMOP00000011651	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000005408	ENSGMOP00000011688	ENSGMOP00000005408	ENSGMOP00000011688	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000005408	ENSGMOP00000011745	ENSGMOP00000005408	ENSGMOP00000011745	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000005408	ENSGMOP00000011750	ENSGMOP00000005408	ENSGMOP00000011750	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000005408	ENSGMOP00000011758	ENSGMOP00000005408	ENSGMOP00000011758	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000005408	ENSGMOP00000014654	ENSGMOP00000005408	ENSGMOP00000014654	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.699
ENSGMOP00000005408	ENSGMOP00000016255	ENSGMOP00000005408	ENSGMOP00000016255	Guanine nucleotide binding protein (G protein), alpha 14a.	annotation not available	0.498
ENSGMOP00000011651	ENSGMOP00000005393	ENSGMOP00000011651	ENSGMOP00000005393	annotation not available	annotation not available	0.498
ENSGMOP00000011651	ENSGMOP00000005408	ENSGMOP00000011651	ENSGMOP00000005408	annotation not available	Guanine nucleotide binding protein (G protein), alpha 14a.	0.498

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006383

Transcription by RNA polymerase III

6 of 20

2.48

4.96

1.46e-10

GO:0006384

Transcription initiation from RNA polymerase III promoter

4 of 6

2.83

3.83

7.83e-08

GO:0006351

Transcription, DNA-templated

8 of 185

1.64

2.93

2.04e-09

GO:0006352

DNA-templated transcription, initiation

5 of 54

1.97

2.8

8.23e-07

GO:0070898

RNA polymerase III preinitiation complex assembly

2 of 2

3.0

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 16

2.28

1.61

0.00092

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.41

0.0028

GO:0000995

RNA polymerase III general transcription initiation factor activity

2 of 2

3.0

1.41

0.0028

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.61

1.31

0.0041

GO:0030151

Molybdenum ion binding

2 of 11

2.26

1.14

0.0077

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

5 of 5

3.0

5.49

6.98e-11

GO:0000127

Transcription factor TFIIIC complex

3 of 3

3.0

2.96

4.07e-06

GO:0000126

Transcription factor TFIIIB complex

2 of 2

3.0

1.64

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:834

Transcription factor TFIIIC complex, and Histidine phosphatase superfamily, clade-1

4 of 5

2.91

3.77

1.14e-07

CL:1661

RNA polymerase III complex, and Transcription factor TFIIIB complex

3 of 20

2.18

1.84

0.00028

CL:13449

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Cytochrome b5, heme-binding site

2 of 7

2.46

1.42

0.0024

CL:1481

RNA Polymerase II Pre-transcription Events, and RNA polymerase

4 of 117

1.54

1.41

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76046

RNA Polymerase III Transcription Initiation

7 of 24

2.47

6.21

1.98e-13

MAP-74158

RNA Polymerase III Transcription

7 of 24

2.47

6.21

1.98e-13

MAP-74160

Gene expression (Transcription)

8 of 540

1.17

1.45

9.18e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 4

2.7

1.03

0.0135

PF00174

Oxidoreductase molybdopterin binding domain

2 of 4

2.7

1.03

0.0135

PF00970

Oxidoreductase FAD-binding domain

2 of 7

2.46

1.02

0.0135

PF00175

Oxidoreductase NAD-binding domain

2 of 15

2.13

0.82

0.0304

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 4

2.7

0.79

0.0374

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 4

2.7

0.79

0.0374

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

2 of 4

2.7

0.79

0.0374

IPR000572

Oxidoreductase, molybdopterin-binding domain

2 of 4

2.7

0.79

0.0374

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 7

2.46

0.78

0.0374

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00384

DNA binding domain with preference for A/T rich regions

2 of 11

2.26

0.9

0.0218

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 24

1.92

0.71

0.0452

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