ENSGMOP00000016463 protein (Gadus morhua) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSGMOP00000016463

annotation not available (261 aa)

Predicted Functional Partners:

ENSGMOP00000013792

0.564

ENSGMOP00000014215

0.564

ENSGMOP00000015742

0.564

ENSGMOP00000020935

0.564

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSGMOP00000013792	ENSGMOP00000014215	EYA transcriptional coactivator and phosphatase 3.	EYA transcriptional coactivator and phosphatase 2.	0.609
ENSGMOP00000013792	ENSGMOP00000015742	EYA transcriptional coactivator and phosphatase 3.	EYA transcriptional coactivator and phosphatase 1.	0.609
ENSGMOP00000013792	ENSGMOP00000016463	EYA transcriptional coactivator and phosphatase 3.	annotation not available	0.564
ENSGMOP00000013792	ENSGMOP00000020935	EYA transcriptional coactivator and phosphatase 3.	EYA transcriptional coactivator and phosphatase 4.	0.606
ENSGMOP00000014215	ENSGMOP00000013792	EYA transcriptional coactivator and phosphatase 2.	EYA transcriptional coactivator and phosphatase 3.	0.609
ENSGMOP00000014215	ENSGMOP00000016463	EYA transcriptional coactivator and phosphatase 2.	annotation not available	0.564
ENSGMOP00000015742	ENSGMOP00000013792	EYA transcriptional coactivator and phosphatase 1.	EYA transcriptional coactivator and phosphatase 3.	0.609
ENSGMOP00000015742	ENSGMOP00000016463	EYA transcriptional coactivator and phosphatase 1.	annotation not available	0.564
ENSGMOP00000016463	ENSGMOP00000013792	annotation not available	EYA transcriptional coactivator and phosphatase 3.	0.564
ENSGMOP00000016463	ENSGMOP00000014215	annotation not available	EYA transcriptional coactivator and phosphatase 2.	0.564
ENSGMOP00000016463	ENSGMOP00000015742	annotation not available	EYA transcriptional coactivator and phosphatase 1.	0.564
ENSGMOP00000016463	ENSGMOP00000020935	annotation not available	EYA transcriptional coactivator and phosphatase 4.	0.564
ENSGMOP00000020935	ENSGMOP00000013792	EYA transcriptional coactivator and phosphatase 4.	EYA transcriptional coactivator and phosphatase 3.	0.606
ENSGMOP00000020935	ENSGMOP00000016463	EYA transcriptional coactivator and phosphatase 4.	annotation not available	0.564

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

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