ENSGMOP00000019198 protein (Gadus morhua) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSGMOP00000019198

Neurolysin (metallopeptidase M3 family). (606 aa)

Predicted Functional Partners:

ENSGMOP00000009133

0.670

ENSGMOP00000014767

0.670

ENSGMOP00000016196

0.670

RIMS2

0.604

ENSGMOP00000004833

0.539

ENSGMOP00000013935

0.539

ENSGMOP00000020361

0.539

ENSGMOP00000007237

0.522

ENSGMOP00000015998

0.496

ENSGMOP00000013570

0.483

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGMOP00000004833	ENSGMOP00000019198	ENSGMOP00000004833	ENSGMOP00000019198	Arylformamidase.	Neurolysin (metallopeptidase M3 family).	0.539
ENSGMOP00000007237	ENSGMOP00000019198	ENSGMOP00000007237	ENSGMOP00000019198	Heat shock 10 protein 1.	Neurolysin (metallopeptidase M3 family).	0.522
ENSGMOP00000009133	ENSGMOP00000019198	ENSGMOP00000009133	ENSGMOP00000019198	Kininogen 1.	Neurolysin (metallopeptidase M3 family).	0.670
ENSGMOP00000013570	ENSGMOP00000019198	ENSGMOP00000013570	ENSGMOP00000019198	Lumican.	Neurolysin (metallopeptidase M3 family).	0.483
ENSGMOP00000013935	ENSGMOP00000019198	ENSGMOP00000013935	ENSGMOP00000019198	Lipase, hormone-sensitive a.	Neurolysin (metallopeptidase M3 family).	0.539
ENSGMOP00000013935	ENSGMOP00000020361	ENSGMOP00000013935	ENSGMOP00000020361	Lipase, hormone-sensitive a.	Lipase, hormone-sensitive b.	0.850
ENSGMOP00000014767	ENSGMOP00000019198	ENSGMOP00000014767	ENSGMOP00000019198	Arylacetamide deacetylase.	Neurolysin (metallopeptidase M3 family).	0.670
ENSGMOP00000015998	ENSGMOP00000019198	ENSGMOP00000015998	ENSGMOP00000019198	Pitrilysin metallopeptidase 1.	Neurolysin (metallopeptidase M3 family).	0.496
ENSGMOP00000016196	ENSGMOP00000019198	ENSGMOP00000016196	ENSGMOP00000019198	annotation not available	Neurolysin (metallopeptidase M3 family).	0.670
ENSGMOP00000019198	ENSGMOP00000004833	ENSGMOP00000019198	ENSGMOP00000004833	Neurolysin (metallopeptidase M3 family).	Arylformamidase.	0.539
ENSGMOP00000019198	ENSGMOP00000007237	ENSGMOP00000019198	ENSGMOP00000007237	Neurolysin (metallopeptidase M3 family).	Heat shock 10 protein 1.	0.522
ENSGMOP00000019198	ENSGMOP00000009133	ENSGMOP00000019198	ENSGMOP00000009133	Neurolysin (metallopeptidase M3 family).	Kininogen 1.	0.670
ENSGMOP00000019198	ENSGMOP00000013570	ENSGMOP00000019198	ENSGMOP00000013570	Neurolysin (metallopeptidase M3 family).	Lumican.	0.483
ENSGMOP00000019198	ENSGMOP00000013935	ENSGMOP00000019198	ENSGMOP00000013935	Neurolysin (metallopeptidase M3 family).	Lipase, hormone-sensitive a.	0.539
ENSGMOP00000019198	ENSGMOP00000014767	ENSGMOP00000019198	ENSGMOP00000014767	Neurolysin (metallopeptidase M3 family).	Arylacetamide deacetylase.	0.670
ENSGMOP00000019198	ENSGMOP00000015998	ENSGMOP00000019198	ENSGMOP00000015998	Neurolysin (metallopeptidase M3 family).	Pitrilysin metallopeptidase 1.	0.496
ENSGMOP00000019198	ENSGMOP00000016196	ENSGMOP00000019198	ENSGMOP00000016196	Neurolysin (metallopeptidase M3 family).	annotation not available	0.670
ENSGMOP00000019198	ENSGMOP00000020361	ENSGMOP00000019198	ENSGMOP00000020361	Neurolysin (metallopeptidase M3 family).	Lipase, hormone-sensitive b.	0.539
ENSGMOP00000019198	RIMS2	ENSGMOP00000019198	ENSGMOP00000006093	Neurolysin (metallopeptidase M3 family).	Regulating synaptic membrane exocytosis 2.	0.604
ENSGMOP00000020361	ENSGMOP00000013935	ENSGMOP00000020361	ENSGMOP00000013935	Lipase, hormone-sensitive b.	Lipase, hormone-sensitive a.	0.850

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007017

Microtubule-based process

8 of 721

1.33

1.67

3.08e-06

GO:0010970

Transport along microtubule

4 of 115

1.83

1.36

0.0017

GO:0032402

Melanosome transport

2 of 11

2.55

0.8

0.0349

GO:1902850

Microtubule cytoskeleton organization involved in mitosis

3 of 109

1.73

0.75

0.0349

GO:0051650

Establishment of vesicle localization

3 of 122

1.68

0.74

0.0349

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005869

Dynactin complex

6 of 15

2.89

6.79

1.52e-13

GO:0005875

Microtubule associated complex

9 of 144

2.08

5.8

3.45e-15

GO:0030286

Dynein complex

4 of 58

2.13

2.63

4.76e-06

GO:0005813

Centrosome

8 of 554

1.45

2.28

1.36e-08

GO:0000776

Kinetochore

4 of 127

1.78

1.88

7.64e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36107127

(2022) Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

6 of 9

3.11

6.48

1.08e-12

PMID:36071160

(2022) Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

3 of 9

2.81

1.81

0.00051

PMID:33734450

(2021) Cryo-EM reveals the complex architecture of dynactins shoulder region and pointed end.

3 of 8

2.86

1.81

0.00051

PMID:18437411

(2008) The mammalian centrosome and its functional significance.

3 of 18

2.51

1.45

0.0021

PMID:33523880

(2021) The Arp111 minifilament of dynactin primes the endosomal Arp23 complex.

3 of 22

2.42

1.38

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15025

Cytoplasmic dynein complex, and Dynactin complex

11 of 33

2.81

13.02

3.35e-27

CL:15064

Dynactin complex, and F-actin-capping protein subunit alpha/beta

9 of 12

3.16

12.32

5.81e-24

CL:15067

Dynactin complex

7 of 7

3.29

9.61

1.83e-18

CL:15029

Mixed, incl. Dynein light chain, type 1/2, conserved site, and Dynein family light intermediate chain

2 of 7

2.74

1.28

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc04962

Vasopressin-regulated water reabsorption

7 of 39

2.54

6.83

1.47e-14

ssc05016

Huntington disease

7 of 260

1.72

3.12

2.35e-09

ssc05014

Amyotrophic lateral sclerosis

7 of 306

1.65

2.87

4.79e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-6811436

COPI-independent Golgi-to-ER retrograde traffic

10 of 39

2.7

10.96

2.74e-23

SSC-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

10 of 40

2.68

10.92

2.74e-23

SSC-6807878

COPI-mediated anterograde transport

10 of 80

2.38

8.85

6.35e-21

SSC-2132295

MHC class II antigen presentation

10 of 119

2.21

7.6

1.63e-19

SSC-380259

Loss of Nlp from mitotic centrosomes

6 of 60

2.29

4.97

3.20e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

6 of 7

3.22

7.72

6.14e-15

GOCC:0005875

Microtubule associated complex

9 of 123

2.15

6.2

1.12e-15

GOCC:0015630

Microtubule cytoskeleton

10 of 593

1.51

3.0

2.21e-12

GOCC:0030286

Dynein complex

4 of 57

2.13

2.62

4.97e-06

GOCC:0005868

Cytoplasmic dynein complex

2 of 18

2.33

1.08

0.0102

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 4

2.99

1.16

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011004

Trimeric LpxA-like superfamily

2 of 4

2.99

0.91

0.0225

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