ENSGMOP00000021787 protein (Gadus morhua) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSGMOP00000021787

annotation not available (303 aa)

Predicted Functional Partners:

ENSGMOP00000011920

0.782

ENSGMOP00000002788

0.780

ENSGMOP00000006943

0.780

ENSGMOP00000005317

0.734

ENSGMOP00000018733

0.734

ENSGMOP00000005934

0.731

ENSGMOP00000003352

0.688

ENSGMOP00000018274

0.672

ENSGMOP00000002494

0.671

ENSGMOP00000014196

0.667

Your Current Organism:

Gadus morhua

NCBI taxonomy Id: 8049
Other names: Atlantic cod, G. morhua

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSGMOP00000002494	ENSGMOP00000002788	annotation not available	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	0.668
ENSGMOP00000002494	ENSGMOP00000003352	annotation not available	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	0.880
ENSGMOP00000002494	ENSGMOP00000005317	annotation not available	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like.	0.845
ENSGMOP00000002494	ENSGMOP00000005934	annotation not available	Si:dkey-160o24.3.	0.849
ENSGMOP00000002494	ENSGMOP00000006943	annotation not available	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2.	0.845
ENSGMOP00000002494	ENSGMOP00000011920	annotation not available	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3.	0.668
ENSGMOP00000002494	ENSGMOP00000018274	annotation not available	ST3 beta-galactoside alpha-2,3-sialyltransferase 3b.	0.864
ENSGMOP00000002494	ENSGMOP00000018733	annotation not available	Si:dkey-199f5.8.	0.673
ENSGMOP00000002494	ENSGMOP00000021787	annotation not available	annotation not available	0.671
ENSGMOP00000002788	ENSGMOP00000002494	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	annotation not available	0.668
ENSGMOP00000002788	ENSGMOP00000003352	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	0.745
ENSGMOP00000002788	ENSGMOP00000005934	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	Si:dkey-160o24.3.	0.849
ENSGMOP00000002788	ENSGMOP00000011920	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3.	0.839
ENSGMOP00000002788	ENSGMOP00000018274	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	ST3 beta-galactoside alpha-2,3-sialyltransferase 3b.	0.710
ENSGMOP00000002788	ENSGMOP00000018733	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	Si:dkey-199f5.8.	0.840
ENSGMOP00000002788	ENSGMOP00000021787	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	annotation not available	0.780
ENSGMOP00000003352	ENSGMOP00000002494	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	annotation not available	0.880
ENSGMOP00000003352	ENSGMOP00000002788	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4.	0.745
ENSGMOP00000003352	ENSGMOP00000005317	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like.	0.880
ENSGMOP00000003352	ENSGMOP00000006943	Fucosyltransferase 8b (alpha (1,6) fucosyltransferase).	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2.	0.880

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.952

expected number of edges:

11

PPI enrichment p-value:

4.7e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031145

Anaphase-promoting complex-dependent catabolic process

5 of 19

2.68

4.3

7.59e-09

GO:0007091

Metaphase/anaphase transition of mitotic cell cycle

4 of 7

3.02

3.95

5.69e-08

GO:0070979

Protein K11-linked ubiquitination

5 of 30

2.49

3.89

2.89e-08

GO:0010965

Regulation of mitotic sister chromatid separation

5 of 61

2.18

3.18

3.16e-07

GO:0033045

Regulation of sister chromatid segregation

5 of 69

2.12

3.05

4.74e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

5 of 21

2.64

4.6

1.66e-09

GO:0005929

Cilium

5 of 627

1.17

0.9

0.0030

GO:0005815

Microtubule organizing center

5 of 729

1.1

0.8

0.0053

GO:0005856

Cytoskeleton

8 of 2062

0.85

0.73

0.00046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8874

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

5 of 11

2.92

5.11

3.23e-10

CL:8877

Metaphase/anaphase transition of cell cycle, and Anaphase-promoting complex, subunit 10 (APC10)

3 of 5

3.04

2.95

4.32e-06

CL:22447

Tongue morphogenesis, and Retinal pigment epithelium development

3 of 5

3.04

2.95

4.32e-06

CL:22315

Mixed, incl. Intraciliary transport particle, and Ciliary transition zone

4 of 71

2.01

2.22

2.84e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04914

Progesterone-mediated oocyte maturation

4 of 75

1.99

2.24

2.32e-05

cfa04114

Oocyte meiosis

4 of 102

1.86

2.05

3.81e-05

cfa04110

Cell cycle

4 of 106

1.84

2.04

3.81e-05

cfa04120

Ubiquitin mediated proteolysis

4 of 126

1.77

1.96

4.32e-05

cfa05166

Human T-cell leukemia virus 1 infection

4 of 173

1.63

1.68

0.00012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-179409

APC-Cdc20 mediated degradation of Nek2A

6 of 25

2.64

5.79

5.73e-12

CFA-176407

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

5 of 20

2.66

4.8

6.96e-10

CFA-176412

Phosphorylation of the APC/C

5 of 21

2.64

4.78

6.96e-10

CFA-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

5 of 21

2.64

4.78

6.96e-10

CFA-174048

APC/C:Cdc20 mediated degradation of Cyclin B

5 of 24

2.58

4.74

6.96e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005680

Anaphase-promoting complex

5 of 18

2.71

4.75

1.01e-09

GOCC:0005929

Cilium

4 of 433

1.23

0.72

0.0192

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0802

TPR repeat

3 of 105

1.72

1.0

0.0098

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12895

Anaphase-promoting complex, cyclosome, subunit 3

2 of 2

3.26

1.35

0.0037

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 88

1.8

0.98

0.0115

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