STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC105938548Peroxisome proliferator-activated receptor alpha b. (469 aa)    
Predicted Functional Partners:
ppargc1a
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
   
 0.973
ppara
Peroxisome proliferator-activated receptor alpha a.
  
  
 
0.953
med1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.950
rxra
Retinoid X receptor, alpha a.
    
0.933
sirt1
Sirtuin 1.
    
 0.876
LOC105924936
CREB binding protein b.
    
 0.873
crebbp
CREB binding protein a.
    
 0.873
ncor2
Nuclear receptor corepressor 2.
    
 0.855
ncor1
Nuclear receptor corepressor 1.
    
 0.855
HDAC3
Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    
 0.825
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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