STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nuak2NUAK family, SNF1-like kinase, 2. (530 aa)    
Predicted Functional Partners:
stk11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
    
0.715
ENSFHEP00000000852
Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.
      
 0.619
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17.
      
 0.618
arhgap18
Rho GTPase activating protein 18.
   
  
 0.527
amotl2
Angiomotin like 2a.
   
  
 0.527
LOC105934647
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.520
fbln7
Fibulin-7.
      
 0.422
LOC105925200
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
0.420
LOC105939250
Tribbles pseudokinase 3.
  
 
0.410
prkaa1
Non-specific serine/threonine protein kinase.
  
 
0.406
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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