STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSFHEP00000005564HECT and RLD domain containing E3 ubiquitin protein ligase 3. (941 aa)    
Predicted Functional Partners:
ENSFHEP00000032744
Uncharacterized protein.
  
  
 
0.726
psmb2
Proteasome subunit beta.
    
 
 0.725
LOC105934647
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.704
trip12
Thyroid hormone receptor interactor 12.
     
0.685
ENSFHEP00000005091
Forkhead box D1.
    
 0.660
LOC105929699
Forkhead box L1.
    
 0.660
MAF
MAF bZIP transcription factor; Belongs to the bZIP family.
      
 0.637
ENSFHEP00000034606
HECT domain-containing protein.
   
 
0.616
rpl7
Ribosomal protein L7.
    
 
 0.584
rpl7l1
Ribosomal protein L7-like 1.
    
 
 0.584
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.