LOC105920066 protein (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC105920066

Golgin A7 family, member Ba. (170 aa)

Predicted Functional Partners:

zdhhc8

0.728

zdhhc9

0.724

zdhhc5

0.696

LOC105921094

0.696

LOC105930809

0.677

LOC105933908

0.629

LOC105925989

0.629

zdhhc18

0.629

ENSFHEP00000018958

0.629

LOC105918676

0.629

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000018958	LOC105920066	ENSFHEP00000018958	ENSFHEP00000007768	Uncharacterized protein.	Golgin A7 family, member Ba.	0.629
ENSFHEP00000018958	LOC105925989	ENSFHEP00000018958	ENSFHEP00000008122	Uncharacterized protein.	Uncharacterized protein.	0.690
ENSFHEP00000018958	zdhhc18	ENSFHEP00000018958	ENSFHEP00000013984	Uncharacterized protein.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.633
ENSFHEP00000018958	zdhhc9	ENSFHEP00000018958	ENSFHEP00000031457	Uncharacterized protein.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.439
LOC105918676	LOC105920066	ENSFHEP00000029954	ENSFHEP00000007768	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Golgin A7 family, member Ba.	0.629
LOC105920066	ENSFHEP00000018958	ENSFHEP00000007768	ENSFHEP00000018958	Golgin A7 family, member Ba.	Uncharacterized protein.	0.629
LOC105920066	LOC105918676	ENSFHEP00000007768	ENSFHEP00000029954	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.629
LOC105920066	LOC105921094	ENSFHEP00000007768	ENSFHEP00000029921	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.696
LOC105920066	LOC105925989	ENSFHEP00000007768	ENSFHEP00000008122	Golgin A7 family, member Ba.	Uncharacterized protein.	0.629
LOC105920066	LOC105930809	ENSFHEP00000007768	ENSFHEP00000017805	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.677
LOC105920066	LOC105933908	ENSFHEP00000007768	ENSFHEP00000004349	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.629
LOC105920066	zdhhc18	ENSFHEP00000007768	ENSFHEP00000013984	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.629
LOC105920066	zdhhc5	ENSFHEP00000007768	ENSFHEP00000013274	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.696
LOC105920066	zdhhc8	ENSFHEP00000007768	ENSFHEP00000025091	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.728
LOC105920066	zdhhc9	ENSFHEP00000007768	ENSFHEP00000031457	Golgin A7 family, member Ba.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.724
LOC105921094	LOC105920066	ENSFHEP00000029921	ENSFHEP00000007768	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Golgin A7 family, member Ba.	0.696
LOC105925989	ENSFHEP00000018958	ENSFHEP00000008122	ENSFHEP00000018958	Uncharacterized protein.	Uncharacterized protein.	0.690
LOC105925989	LOC105920066	ENSFHEP00000008122	ENSFHEP00000007768	Uncharacterized protein.	Golgin A7 family, member Ba.	0.629
LOC105930809	LOC105920066	ENSFHEP00000017805	ENSFHEP00000007768	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Golgin A7 family, member Ba.	0.677
LOC105933908	LOC105920066	ENSFHEP00000004349	ENSFHEP00000007768	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Golgin A7 family, member Ba.	0.629

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

11

PPI enrichment p-value:

2.98e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

7 of 58

2.06

4.23

2.26e-10

GO:0000054

Ribosomal subunit export from nucleus

4 of 16

2.38

2.97

1.79e-06

GO:0042254

Ribosome biogenesis

9 of 241

1.55

2.86

2.26e-10

GO:0042255

Ribosome assembly

4 of 32

2.08

2.4

1.35e-05

GO:0000027

Ribosomal large subunit assembly

3 of 16

2.26

1.98

0.00016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043023

Ribosomal large subunit binding

2 of 7

2.44

0.74

0.0451

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

3 of 23

2.1

1.6

0.00079

GO:0005730

Nucleolus

5 of 197

1.39

1.23

0.00075

GO:1990904

Ribonucleoprotein complex

4 of 350

1.04

0.61

0.0241

GO:0043232

Intracellular non-membrane-bounded organelle

6 of 862

0.83

0.55

0.0119

GO:0005634

Nucleus

8 of 1734

0.65

0.45

0.0101

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4429

Ribosomal large subunit biogenesis, and Nucleolar protein,Nop52

10 of 44

2.34

8.3

7.20e-20

CL:4433

Ribosomal large subunit biogenesis, and GTP-binding protein, orthogonal bundle domain superfamily

6 of 32

2.26

4.75

8.55e-11

CL:4483

Mixed, incl. Ribosomal protein S8e, and Ribosomal protein L24e

3 of 5

2.76

2.87

5.13e-06

CL:4442

Ribosome biogenesis

2 of 5

2.58

1.46

0.0021

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

6 of 69

1.92

3.46

6.58e-09

map03010

Ribosome

3 of 153

1.27

0.65

0.0336

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

3 of 86

1.53

0.68

0.0406

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 758

0.88

0.49

0.0406

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

3 of 17

2.23

1.92

0.00021

KW-0539

Nucleus

5 of 285

1.23

1.09

0.00069

KW-0963

Cytoplasm

3 of 137

1.32

0.71

0.0262

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01926

50S ribosome-binding GTPase

3 of 19

2.18

1.55

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006073

GTP binding domain

3 of 13

2.35

1.58

0.0011

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 4

2.68

0.96

0.0179

IPR022755

Zinc finger, double-stranded RNA binding

2 of 7

2.44

0.85

0.0286

IPR003604

Matrin/U1-C-like, C2H2-type zinc finger

2 of 8

2.38

0.84

0.0286

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