c1galt1c1 protein (Fundulus heteroclitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

c1galt1c1

C1GALT1-specific chaperone 1. (319 aa)

Predicted Functional Partners:

LOC105935385

0.977

LOC105937047

0.966

ENSFHEP00000009521

0.964

st3gal2

0.964

LOC105928248

0.964

gcnt3

0.963

gcnt4

0.960

GALNT5

0.952

LOC105939245

0.949

LOC105918572

0.949

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009521	GALNT5	ENSFHEP00000009521	ENSFHEP00000019827	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Polypeptide N-acetylgalactosaminyltransferase.	0.945
ENSFHEP00000009521	LOC105918572	ENSFHEP00000009521	ENSFHEP00000031959	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Polypeptide N-acetylgalactosaminyltransferase.	0.940
ENSFHEP00000009521	LOC105928248	ENSFHEP00000009521	ENSFHEP00000027377	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.953
ENSFHEP00000009521	LOC105935385	ENSFHEP00000009521	ENSFHEP00000015046	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.948
ENSFHEP00000009521	LOC105937047	ENSFHEP00000009521	ENSFHEP00000011883	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b.	0.965
ENSFHEP00000009521	LOC105939245	ENSFHEP00000009521	ENSFHEP00000022533	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	ST3 beta-galactoside alpha-2,3-sialyltransferase 8; Belongs to the glycosyltransferase 29 family.	0.948
ENSFHEP00000009521	c1galt1c1	ENSFHEP00000009521	ENSFHEP00000015968	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	C1GALT1-specific chaperone 1.	0.964
ENSFHEP00000009521	gcnt3	ENSFHEP00000009521	ENSFHEP00000021936	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	0.495
ENSFHEP00000009521	gcnt4	ENSFHEP00000009521	ENSFHEP00000005188	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	Si:dkeyp-87d8.8.	0.459
ENSFHEP00000009521	st3gal2	ENSFHEP00000009521	ENSFHEP00000015851	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family.	0.949
GALNT5	ENSFHEP00000009521	ENSFHEP00000019827	ENSFHEP00000009521	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.945
GALNT5	LOC105928248	ENSFHEP00000019827	ENSFHEP00000027377	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.927
GALNT5	LOC105937047	ENSFHEP00000019827	ENSFHEP00000011883	Polypeptide N-acetylgalactosaminyltransferase.	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b.	0.960
GALNT5	c1galt1c1	ENSFHEP00000019827	ENSFHEP00000015968	Polypeptide N-acetylgalactosaminyltransferase.	C1GALT1-specific chaperone 1.	0.952
GALNT5	gcnt3	ENSFHEP00000019827	ENSFHEP00000021936	Polypeptide N-acetylgalactosaminyltransferase.	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.	0.729
GALNT5	gcnt4	ENSFHEP00000019827	ENSFHEP00000005188	Polypeptide N-acetylgalactosaminyltransferase.	Si:dkeyp-87d8.8.	0.629
LOC105918572	ENSFHEP00000009521	ENSFHEP00000031959	ENSFHEP00000009521	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.940
LOC105918572	LOC105928248	ENSFHEP00000031959	ENSFHEP00000027377	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	0.919
LOC105918572	LOC105937047	ENSFHEP00000031959	ENSFHEP00000011883	Polypeptide N-acetylgalactosaminyltransferase.	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b.	0.950
LOC105918572	c1galt1c1	ENSFHEP00000031959	ENSFHEP00000015968	Polypeptide N-acetylgalactosaminyltransferase.	C1GALT1-specific chaperone 1.	0.949

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.745

expected number of edges:

28

PPI enrichment p-value:

0.147

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990544

Mitochondrial ATP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:0140021

Mitochondrial ADP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:1901029

Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

3 of 11

2.65

2.02

0.00019

GO:1901526

Positive regulation of mitophagy

2 of 9

2.56

1.06

0.0116

GO:1990845

Adaptive thermogenesis

2 of 21

2.19

0.8

0.0340

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005471

ATP:ADP antiporter activity

3 of 4

3.09

2.6

1.90e-05

GO:0017077

Oxidative phosphorylation uncoupler activity

2 of 5

2.82

1.51

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005757

Mitochondrial permeability transition pore complex

3 of 10

2.69

2.22

8.08e-05

GO:0005815

Microtubule organizing center

6 of 749

1.12

0.96

0.0010

GO:0015630

Microtubule cytoskeleton

7 of 1238

0.97

0.81

0.0010

GO:0005814

Centriole

3 of 145

1.53

0.81

0.0204

GO:0005740

Mitochondrial envelope

5 of 641

1.11

0.77

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13605

Mitochondrial permeability transition pore complex, and TspO/MBR-related protein

3 of 13

2.58

1.87

0.00036

CL:12648

Post-chaperonin tubulin folding pathway, and Trafficking of myristoylated proteins to the cilium

3 of 13

2.58

1.87

0.00036

CL:13609

Mitochondrial permeability transition pore complex, and Porin, eukaryotic type

2 of 7

2.67

1.16

0.0078

CL:2389

Mixed, incl. Axonemal microtubule, and Tubulin/FtsZ, 2-layer sandwich domain

3 of 103

1.68

0.88

0.0172

CL:2422

Axonemal microtubule, and DM10 domain

2 of 22

2.17

0.84

0.0272

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 140

1.55

0.77

0.0265

map05017

Spinocerebellar ataxia

3 of 155

1.5

0.76

0.0265

map04218

Cellular senescence

3 of 188

1.42

0.74

0.0265

map04217

Necroptosis

3 of 180

1.44

0.74

0.0265

map04022

cGMP-PKG signaling pathway

3 of 179

1.44

0.74

0.0265

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-83936

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

5 of 13

2.8

4.99

4.15e-10

MAP-425397

Transport of vitamins, nucleosides, and related molecules

5 of 52

2.2

3.41

1.00e-07

MAP-425407

SLC-mediated transmembrane transport

5 of 309

1.43

1.35

0.00037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005757

Mitochondrial permeability transition pore complex

3 of 5

2.99

2.61

1.79e-05

GOCC:0005740

Mitochondrial envelope

5 of 418

1.29

1.05

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00153

Mitochondrial carrier protein

3 of 51

1.99

1.08

0.0086

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007714

CFA20 domain

3 of 3

3.22

2.57

2.25e-05

IPR002113

ADP/ATP carrier protein, eukaryotic type

3 of 3

3.22

2.57

2.25e-05

IPR002067

Mitochondrial carrier protein

3 of 27

2.26

1.5

0.0015

IPR044612

ADP-ribosylation factor-like protein 2/3

2 of 2

3.22

1.37

0.0034

IPR040441

Cilia- and flagella-associated protein 20/CFAP20DC

2 of 2

3.22

1.37

0.0034

(more ...)

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