ptch1 protein (Fundulus heteroclitus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ptch1

Patched 1. (1417 aa)

Predicted Functional Partners:

shh

0.994

smo

0.994

dhh

0.991

LOC105916426

0.988

LOC105931887

0.986

cdon

0.976

boc

0.973

ENSFHEP00000003609

0.967

smurf1

0.966

SMURF2

0.966

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003609	LOC105916426	ENSFHEP00000003609	ENSFHEP00000029057	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.952
ENSFHEP00000003609	LOC105931887	ENSFHEP00000003609	ENSFHEP00000007157	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.962
ENSFHEP00000003609	boc	ENSFHEP00000003609	ENSFHEP00000031259	Growth arrest-specific 1a.	BOC cell adhesion associated, oncogene regulated.	0.967
ENSFHEP00000003609	cdon	ENSFHEP00000003609	ENSFHEP00000033708	Growth arrest-specific 1a.	Cell adhesion associated, oncogene regulated.	0.971
ENSFHEP00000003609	dhh	ENSFHEP00000003609	ENSFHEP00000000080	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.961
ENSFHEP00000003609	ptch1	ENSFHEP00000003609	ENSFHEP00000016159	Growth arrest-specific 1a.	Patched 1.	0.967
ENSFHEP00000003609	shh	ENSFHEP00000003609	ENSFHEP00000014527	Growth arrest-specific 1a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.963
ENSFHEP00000003609	smo	ENSFHEP00000003609	ENSFHEP00000018258	Growth arrest-specific 1a.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.503
LOC105916426	ENSFHEP00000003609	ENSFHEP00000029057	ENSFHEP00000003609	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Growth arrest-specific 1a.	0.952
LOC105916426	boc	ENSFHEP00000029057	ENSFHEP00000031259	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	BOC cell adhesion associated, oncogene regulated.	0.979
LOC105916426	cdon	ENSFHEP00000029057	ENSFHEP00000033708	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Cell adhesion associated, oncogene regulated.	0.979
LOC105916426	dhh	ENSFHEP00000029057	ENSFHEP00000000080	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.727
LOC105916426	ptch1	ENSFHEP00000029057	ENSFHEP00000016159	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 1.	0.988
LOC105916426	shh	ENSFHEP00000029057	ENSFHEP00000014527	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.736
LOC105916426	smo	ENSFHEP00000029057	ENSFHEP00000018258	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.783
LOC105931887	ENSFHEP00000003609	ENSFHEP00000007157	ENSFHEP00000003609	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Growth arrest-specific 1a.	0.962
LOC105931887	boc	ENSFHEP00000007157	ENSFHEP00000031259	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	BOC cell adhesion associated, oncogene regulated.	0.982
LOC105931887	cdon	ENSFHEP00000007157	ENSFHEP00000033708	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Cell adhesion associated, oncogene regulated.	0.984
LOC105931887	dhh	ENSFHEP00000007157	ENSFHEP00000000080	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.913
LOC105931887	ptch1	ENSFHEP00000007157	ENSFHEP00000016159	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 1.	0.986

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Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.528

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031419

Cobalamin binding

5 of 13

2.03

2.83

9.75e-07

GO:0016866

Intramolecular transferase activity

5 of 19

1.86

2.51

2.40e-06

GO:0046872

Metal ion binding

7 of 491

0.6

0.36

0.0419

GO:0036094

Small molecule binding

7 of 512

0.58

0.35

0.0424

GO:0043167

Ion binding

9 of 859

0.46

0.31

0.0327

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2194

Cobalamin binding, and Glyoxalase-like domain

7 of 12

2.21

4.9

2.12e-11

CL:2196

Mixed, incl. Methylmalonyl-CoA mutase, and Glyoxalase-like domain

3 of 6

2.14

1.66

0.00062

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00280

Valine, leucine and isoleucine degradation

8 of 33

1.83

4.01

8.96e-12

map00640

Propanoate metabolism

7 of 36

1.73

3.24

1.14e-09

map00630

Glyoxylate and dicarboxylate metabolism

7 of 54

1.56

2.58

1.01e-08

map01200

Carbon metabolism

7 of 147

1.12

1.28

5.53e-06

map01120

Microbial metabolism in diverse environments

7 of 399

0.69

0.52

0.0031

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02310

B12 binding domain

4 of 8

2.14

2.36

2.00e-05

PF13468

Glyoxalase-like domain

2 of 3

2.27

0.85

0.0267

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036724

Cobalamin-binding domain superfamily

4 of 7

2.2

2.27

3.61e-05

IPR006158

Cobalamin (vitamin B12)-binding domain

4 of 7

2.2

2.27

3.61e-05

IPR006159

Methylmalonyl-CoA mutase, C-terminal

3 of 3

2.44

1.9

0.00028

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