STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (693 aa)    
Predicted Functional Partners:
sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.950
NCSTN
Nicastrin.
    
 0.937
ide
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.924
ENSFHEP00000001825
Tumor necrosis factor receptor superfamily, member 21.
    
 
 0.903
pitrm1
Pitrilysin metallopeptidase 1.
    
 
 0.898
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    
 0.890
LOC105939523
Apolipoprotein Eb.
    
 0.841
apbb3
Amyloid beta (A4) precursor protein-binding, family B, member 3.
    
 0.840
gulp1
GULP PTB domain containing engulfment adaptor 1a.
    
 
 0.806
ENSFHEP00000003204
Uncharacterized protein; Belongs to the synuclein family.
    
 0.805
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.